Highlights and News

New data reveals ethnic disparities in early rheumatoid arthritis treatment - University of Birmingham
New data reveals ethnic disparities in early rheumatoid arthritis treatment  University of Birmingham
Factors associated with biological and targeted synthetic disease-modifying antirheumatic drug initiation for rheumatoid arthritis in underserved patient groups in England and Wales, UK: a national cohort study - The Lancet
Factors associated with biological and targeted synthetic disease-modifying antirheumatic drug initiation for rheumatoid arthritis in underserved patient groups in England and Wales, UK: a national cohort study  The Lancet
Rheumatoid Arthritis Life Expectancy: What You Need to Know - HealthCentral
Rheumatoid Arthritis Life Expectancy: What You Need to Know  HealthCentral
Rheumatoid arthritis: Do gut bacteria play a role? - Medical News Today
Rheumatoid arthritis: Do gut bacteria play a role?  Medical News Today
The Role of Ultrasound Across the Inflammatory Arthritis Continuum: Focus on "At-Risk” Individuals - Frontiers
The Role of Ultrasound Across the Inflammatory Arthritis Continuum: Focus on "At-Risk” Individuals  Frontiers
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure' - Healio
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure'  Healio
Inflammatory Arthritis: Rheumatoid, Reactive & Others - HSS | Hospital for Special Surgery
Inflammatory Arthritis: Rheumatoid, Reactive & Others  HSS | Hospital for Special Surgery
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis - Wiley Online Library
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis  Wiley Online Library
Clinical Trials and Resources - Arthritis Foundation
Clinical Trials and Resources  Arthritis Foundation
The 4 Stages of Rheumatoid Arthritis Progression - CreakyJoints
The 4 Stages of Rheumatoid Arthritis Progression  CreakyJoints
Rheumatology - Northumbria Healthcare NHS Foundation Trust
Rheumatology  Northumbria Healthcare NHS Foundation Trust
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients - Nature
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients  Nature
Arthritis drugs may reduce mortality and time in ICU for sickest COVID patients - Imperial College London
Arthritis drugs may reduce mortality and time in ICU for sickest COVID patients  Imperial College London
Rheumatoid arthritis: features, causes and diagnosis - The Pharmaceutical Journal
Rheumatoid arthritis: features, causes and diagnosis  The Pharmaceutical Journal
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank - Frontiers
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank  Frontiers
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial - The Lancet
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial  The Lancet
Rheumatoid Arthritis: Autoimmune Joint Inflammation - HSS | Hospital for Special Surgery
Rheumatoid Arthritis: Autoimmune Joint Inflammation  HSS | Hospital for Special Surgery
11 Signs Your Rheumatoid Arthritis May Be Getting Worse, and You Should See a Doctor - CreakyJoints
11 Signs Your Rheumatoid Arthritis May Be Getting Worse, and You Should See a Doctor  CreakyJoints
Rheumatoid arthritis - The Lancet
Rheumatoid arthritis  The Lancet
Global, regional, and national burden of rheumatoid arthritis, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021 - The Lancet
Global, regional, and national burden of rheumatoid arthritis, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021  The Lancet
Treatment to target in rheumatoid arthritis - Nursing Times
Treatment to target in rheumatoid arthritis  Nursing Times
Arthritis drug effective in treating sickest COVID-19 patients - Imperial College London
Arthritis drug effective in treating sickest COVID-19 patients  Imperial College London
Osteoarthritis - World Health Organization (WHO)
Osteoarthritis  World Health Organization (WHO)
Psoriatic Arthritis: Symptoms, Diagnosis, and Treatment - Arthritis Foundation
Psoriatic Arthritis: Symptoms, Diagnosis, and Treatment  Arthritis Foundation
Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials - The Lancet
Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials  The Lancet
Rheumatoid arthritis and baking soda: The potential benefits - Medical News Today
Rheumatoid arthritis and baking soda: The potential benefits  Medical News Today
Approaches to optimising access to NICE-approved biologic anti-TNFs for patients with rheumatoid arthritis with moderately active disease - BMC Medicine
Approaches to optimising access to NICE-approved biologic anti-TNFs for patients with rheumatoid arthritis with moderately active disease  BMC Medicine
Towards stratified treatment of JIA: machine learning identifies subtypes in response to methotrexate from four UK cohorts - The Lancet
Towards stratified treatment of JIA: machine learning identifies subtypes in response to methotrexate from four UK cohorts  The Lancet
Rheumatoid arthritis diagnosis and management: a clinical update - Nursing Times
Rheumatoid arthritis diagnosis and management: a clinical update  Nursing Times
Asian and older rheumatoid arthritis sufferers 50% less likely to receive targeted treatment, finds study - Medical Xpress
Asian and older rheumatoid arthritis sufferers 50% less likely to receive targeted treatment, finds study  Medical Xpress
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment - Nature
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment  Nature
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal - HealthCentral
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal  HealthCentral
Rheumatoid arthritis - Nature
Rheumatoid arthritis  Nature
Early Menopause, Hormone Replacement Therapy May Raise Rheumatoid Arthritis Risk - Healthline
Early Menopause, Hormone Replacement Therapy May Raise Rheumatoid Arthritis Risk  Healthline
Blocking the immune system in rheumatoid arthritis - The Pharmaceutical Journal
Blocking the immune system in rheumatoid arthritis  The Pharmaceutical Journal
Understanding Rheumatoid Arthritis Lab Tests and Results - HSS | Hospital for Special Surgery
Understanding Rheumatoid Arthritis Lab Tests and Results  HSS | Hospital for Special Surgery
A New Study Sheds Light on the Early Roots of RA - HealthCentral
A New Study Sheds Light on the Early Roots of RA  HealthCentral
Biological disease‐modifying drugs for rheumatoid arthritis - Chaplin - 2020 - Prescriber - Wiley Online Library
Biological disease‐modifying drugs for rheumatoid arthritis - Chaplin - 2020 - Prescriber  Wiley Online Library
The N-Formyl Peptide Receptors and Rheumatoid Arthritis: A Dangerous Liaison or Confusing Relationship? - Frontiers
The N-Formyl Peptide Receptors and Rheumatoid Arthritis: A Dangerous Liaison or Confusing Relationship?  Frontiers
6 Common Questions About Taking Prednisone for Rheumatoid Arthritis - CreakyJoints
6 Common Questions About Taking Prednisone for Rheumatoid Arthritis  CreakyJoints
Clinical implications of synovial tissue phenotypes in rheumatoid arthritis - Frontiers
Clinical implications of synovial tissue phenotypes in rheumatoid arthritis  Frontiers
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis - The New England Journal of Medicine
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis  The New England Journal of Medicine
Biologics for rheumatoid arthritis: How they work - Medical News Today
Biologics for rheumatoid arthritis: How they work  Medical News Today
Failure to act on early signs of rheumatoid arthritis could prove fatal - The Guardian
Failure to act on early signs of rheumatoid arthritis could prove fatal  The Guardian
Identification of novel urinary biomarkers for assessing disease activity and prognosis of rheumatoid arthritis - Nature
Identification of novel urinary biomarkers for assessing disease activity and prognosis of rheumatoid arthritis  Nature
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission - Nature
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission  Nature
Adalimumab is found to be a cost-effective treatment for early-stage Dupuytren's disease - ndph.ox.ac.uk
Adalimumab is found to be a cost-effective treatment for early-stage Dupuytren's disease  ndph.ox.ac.uk
Rheumatoid Arthritis X-Ray: Diagnosis and Evaluation - HealthCentral
Rheumatoid Arthritis X-Ray: Diagnosis and Evaluation  HealthCentral
Palliative care - World Health Organization (WHO)
Palliative care  World Health Organization (WHO)
Turmeric for rheumatoid arthritis: Does it work? - Medical News Today
Turmeric for rheumatoid arthritis: Does it work?  Medical News Today
PolyMyalgia Rheumatica treatment with Methotrexate in Optimal Dose in an Early disease phase (PMR MODE): study protocol for a multicenter double-blind placebo controlled trial - BioMed Central
PolyMyalgia Rheumatica treatment with Methotrexate in Optimal Dose in an Early disease phase (PMR MODE): study protocol for a multicenter double-blind placebo controlled trial  BioMed Central
Efficacy of B-Cell-Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis - The New England Journal of Medicine
Efficacy of B-Cell-Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis  The New England Journal of Medicine
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics - Nature
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics  Nature
Rheumatoid arthritis: management - The Pharmaceutical Journal
Rheumatoid arthritis: management  The Pharmaceutical Journal
8 Signs of Arthritis You Shouldn't Ignore - AARP
8 Signs of Arthritis You Shouldn't Ignore  AARP
UK waiting times for RA and PsA patients: an interview with Dr Marwan Bukhari, Consultant Rheumatologist at the University Hospitals of Morecambe Bay NHS Foundation Trust - News-Medical
UK waiting times for RA and PsA patients: an interview with Dr Marwan Bukhari, Consultant Rheumatologist at the University Hospitals of Morecambe Bay NHS Foundation Trust  News-Medical
Rheumatoid arthritis: How to spot arthritis bumps - location and size - Daily Express
Rheumatoid arthritis: How to spot arthritis bumps - location and size  Daily Express
10 Natural remedies for rheumatoid arthritis - Medical News Today
10 Natural remedies for rheumatoid arthritis  Medical News Today
AVERT trial demonstrates high rates of DAS-defined remission with Orencia® (abatacept) in combination with Methotrexate in adult patients with early rheumatoid arthritis - Drug Target Review
AVERT trial demonstrates high rates of DAS-defined remission with Orencia® (abatacept) in combination with Methotrexate in adult patients with early rheumatoid arthritis  Drug Target Review
Proteolytic enzymes for arthritis pain: Do they help? - Medical News Today
Proteolytic enzymes for arthritis pain: Do they help?  Medical News Today
How does alcohol affect rheumatoid arthritis (RA)? - Medical News Today
How does alcohol affect rheumatoid arthritis (RA)?  Medical News Today
Osteoarthritis in primary care: early diagnosis and management - GPonline
Osteoarthritis in primary care: early diagnosis and management  GPonline
Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health - Nature
Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health  Nature
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients - Nature
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients  Nature
Arthritis warning: The healthy foods that can actually trigger arthritis symptoms - Daily Express
Arthritis warning: The healthy foods that can actually trigger arthritis symptoms  Daily Express
Chinese herbal remedy 'just as effective as methotrexate against arthritis' - Medical News Today
Chinese herbal remedy 'just as effective as methotrexate against arthritis'  Medical News Today
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis - The New England Journal of Medicine
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis  The New England Journal of Medicine
Early Treatment Improves Rheumatoid Arthritis Symptoms, Helps Patients Live Longer, Study Suggests - rheumatoidarthritisnews.com
Early Treatment Improves Rheumatoid Arthritis Symptoms, Helps Patients Live Longer, Study Suggests  rheumatoidarthritisnews.com
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis - The New England Journal of Medicine
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis  The New England Journal of Medicine

Articles/peer reviewed publications and
Lay Summaries

  • B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure.
    Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C; PEAC- R4RA investigators. 
    Arthritis Rheumatol. 2019 Nov 29.
    https://doi.org/10.1002/art.41184
    See Lay Summary




The R4-RA trial is funded by the MRC-NIHR Efficacy and
Mechanism Evaluation Programme