Highlights and News

Location and amount of joint involvement differentiates rheumatoid arthritis into different clinical subsets - Nature
Location and amount of joint involvement differentiates rheumatoid arthritis into different clinical subsets  Nature
Methotrexate oral or subcutaneous for rheumatoid arthritis (MOOSE): study protocol for a multi-centre randomised trial - Springer
Methotrexate oral or subcutaneous for rheumatoid arthritis (MOOSE): study protocol for a multi-centre randomised trial  Springer
New gene study offers arthritis treatment insights - HealthandCare.scot
New gene study offers arthritis treatment insights  HealthandCare.scot
New research reveals shared genetic link between endometriosis and immune conditions - University of Oxford
New research reveals shared genetic link between endometriosis and immune conditions  University of Oxford
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis - Wiley Online Library
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis  Wiley Online Library
Is There a Missing Link in Rheumatoid Arthritis Management? - European Medical Journal
Is There a Missing Link in Rheumatoid Arthritis Management?  European Medical Journal
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial - The Lancet
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial  The Lancet
Rheumatoid arthritis: features, causes and diagnosis - The Pharmaceutical Journal
Rheumatoid arthritis: features, causes and diagnosis  The Pharmaceutical Journal
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank - Frontiers
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank  Frontiers
Refractory Inflammatory Arthritis definition and model generated through patient and multi-disciplinary professional modified Delphi process - medRxiv
Refractory Inflammatory Arthritis definition and model generated through patient and multi-disciplinary professional modified Delphi process  medRxiv
The 4 Stages of Rheumatoid Arthritis Progression - CreakyJoints
The 4 Stages of Rheumatoid Arthritis Progression  CreakyJoints
Understanding Methotrexate - Arthritis Foundation
Understanding Methotrexate  Arthritis Foundation
University of Birmingham receives £3.5 million to study arthritis treatment responses - News-Medical
University of Birmingham receives £3.5 million to study arthritis treatment responses  News-Medical
Rheumatoid arthritis diagnosis and management: a clinical update - Nursing Times
Rheumatoid arthritis diagnosis and management: a clinical update  Nursing Times
Rheumatoid Arthritis Life Expectancy: What You Need to Know - HealthCentral
Rheumatoid Arthritis Life Expectancy: What You Need to Know  HealthCentral
Optimising Response to Advanced Therapies in Rheumatoid Arthritis - Using Prehabilitation to Improve Success? - European Medical Journal
Optimising Response to Advanced Therapies in Rheumatoid Arthritis - Using Prehabilitation to Improve Success?  European Medical Journal
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients - Nature
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients  Nature
Foot and Ankle Care in Inflammatory Arthritis - Arthritis Foundation
Foot and Ankle Care in Inflammatory Arthritis  Arthritis Foundation
Editor's Pick: JAK Inhibitors in the Treatment Algorithm of Rheumatoid Arthritis: A Review - European Medical Journal
Editor's Pick: JAK Inhibitors in the Treatment Algorithm of Rheumatoid Arthritis: A Review  European Medical Journal
Rheumatoid arthritis - The Lancet
Rheumatoid arthritis  The Lancet
Editor's Pick: JAK Inhibitors in Rheumatoid Arthritis - - European Medical Journal
Editor's Pick: JAK Inhibitors in Rheumatoid Arthritis -  European Medical Journal
Rheumatoid arthritis: management - The Pharmaceutical Journal
Rheumatoid arthritis: management  The Pharmaceutical Journal
Blocking the immune system in rheumatoid arthritis - The Pharmaceutical Journal
Blocking the immune system in rheumatoid arthritis  The Pharmaceutical Journal
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment - Nature
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment  Nature
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis - New England Journal of Medicine
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis  New England Journal of Medicine
Clinical implications of synovial tissue phenotypes in rheumatoid arthritis - Frontiers
Clinical implications of synovial tissue phenotypes in rheumatoid arthritis  Frontiers
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission - Nature
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission  Nature
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal - HealthCentral
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal  HealthCentral
Rheumatoid arthritis and baking soda: The potential benefits - Medical News Today
Rheumatoid arthritis and baking soda: The potential benefits  Medical News Today
Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course | Scientific Reports - Nature
Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course | Scientific Reports  Nature
UK waiting times for RA and PsA patients: an interview with Dr Marwan Bukhari, Consultant Rheumatologist at the University Hospitals of Morecambe Bay NHS Foundation Trust - News-Medical
UK waiting times for RA and PsA patients: an interview with Dr Marwan Bukhari, Consultant Rheumatologist at the University Hospitals of Morecambe Bay NHS Foundation Trust  News-Medical
Association between obesity and remission in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs | Scientific Reports - Nature
Association between obesity and remission in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs | Scientific Reports  Nature
Palliative care - World Health Organization (WHO)
Palliative care  World Health Organization (WHO)
Can gold injections treat rheumatoid arthritis? - Medical News Today
Can gold injections treat rheumatoid arthritis?  Medical News Today
Cholesterol Levels and Rheumatoid Arthritis: What's the Link? - HealthCentral
Cholesterol Levels and Rheumatoid Arthritis: What's the Link?  HealthCentral
Rheumatoid Arthritis - UF Health
Rheumatoid Arthritis  UF Health
New drug Bimzelx shows promise as a treatment for psoriatic arthritis - Medical News Today
New drug Bimzelx shows promise as a treatment for psoriatic arthritis  Medical News Today
What Happens at the First Appointment With a Rheumatologist? - Everyday Health
What Happens at the First Appointment With a Rheumatologist?  Everyday Health
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics - Nature
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics  Nature
Rheumatoid arthritis - Nature
Rheumatoid arthritis  Nature
Rheumatoid arthritis: How to spot arthritis bumps - location and size - Daily Express
Rheumatoid arthritis: How to spot arthritis bumps - location and size  Daily Express
Treating rheumatoid arthritis with JAK inhibitors: What to know - Medical News Today
Treating rheumatoid arthritis with JAK inhibitors: What to know  Medical News Today
Early Treatment Boosts Long-term Rheumatoid Arthritis Outcomes - Medscape
Early Treatment Boosts Long-term Rheumatoid Arthritis Outcomes  Medscape
Osteoarthritis in primary care: early diagnosis and management - GPonline
Osteoarthritis in primary care: early diagnosis and management  GPonline
Rheumatoid arthritis: Early menopause among factors for higher risk - Medical News Today
Rheumatoid arthritis: Early menopause among factors for higher risk  Medical News Today
Rheumatoid arthritis: Do gut bacteria play a role? - Medical News Today
Rheumatoid arthritis: Do gut bacteria play a role?  Medical News Today
Health battle has left beloved TV legend in agony - Metro.co.uk
Health battle has left beloved TV legend in agony  Metro.co.uk
Tocilizumab - a new treatment for severe juvenile idiopathic arthritis in children | Research Impact - UCL - UCL | University College London
Tocilizumab - a new treatment for severe juvenile idiopathic arthritis in children | Research Impact - UCL  UCL | University College London
Early Menopause, Hormone Replacement Therapy May Raise Rheumatoid Arthritis Risk - Healthline
Early Menopause, Hormone Replacement Therapy May Raise Rheumatoid Arthritis Risk  Healthline
Rheumatoid arthritis severity scale: How it works and outlook - Medical News Today
Rheumatoid arthritis severity scale: How it works and outlook  Medical News Today
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients - Nature
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients  Nature
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure' - Healio
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure'  Healio
Rheumatoid arthritis: Overweight and obese people at greater risk - Daily Express
Rheumatoid arthritis: Overweight and obese people at greater risk  Daily Express
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis - New England Journal of Medicine
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis  New England Journal of Medicine
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis - New England Journal of Medicine
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis  New England Journal of Medicine

Articles/peer reviewed publications and
Lay Summaries

  • B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure.
    Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C; PEAC- R4RA investigators. 
    Arthritis Rheumatol. 2019 Nov 29.
    https://doi.org/10.1002/art.41184
    See Lay Summary




The R4-RA trial is funded by the MRC-NIHR Efficacy and
Mechanism Evaluation Programme