Highlights and News

Why Rheumatoid Arthritis Remission Rates Remain Stagnant - European Medical Journal
Why Rheumatoid Arthritis Remission Rates Remain Stagnant  European Medical Journal
Rheumatoid arthritis: Pretreatment may delay onset by up to 4 years - MedicalNewsToday
Rheumatoid arthritis: Pretreatment may delay onset by up to 4 years  MedicalNewsToday
New gene study offers arthritis treatment insights - HealthandCare.scot
New gene study offers arthritis treatment insights  HealthandCare.scot
New research reveals shared genetic link between endometriosis and immune conditions - University of Oxford
New research reveals shared genetic link between endometriosis and immune conditions  University of Oxford
International recognition for Stockport NHS rheumatology team - InYourArea
International recognition for Stockport NHS rheumatology team  InYourArea
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis - Wiley Online Library
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis  Wiley Online Library
Links between arthritis therapy and heart disease improvements - University of Leeds
Links between arthritis therapy and heart disease improvements  University of Leeds
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial - The Lancet
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial  The Lancet
Arthritis drug effective in treating sickest COVID-19 patients - Imperial College London
Arthritis drug effective in treating sickest COVID-19 patients  Imperial College London
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients - Nature
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients  Nature
Refractory Inflammatory Arthritis definition and model generated through patient and multi-disciplinary professional modified Delphi process - medRxiv
Refractory Inflammatory Arthritis definition and model generated through patient and multi-disciplinary professional modified Delphi process  medRxiv
The 4 Stages of Rheumatoid Arthritis Progression - CreakyJoints
The 4 Stages of Rheumatoid Arthritis Progression  CreakyJoints
First UK patient treated in ‘OSCAR' COVID-19 research study, trialling experimental arthritis drug as treatment for coronavirus - Manchester University NHS Foundation Trust
First UK patient treated in ‘OSCAR' COVID-19 research study, trialling experimental arthritis drug as treatment for coronavirus  Manchester University NHS Foundation Trust
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank - Frontiers
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank  Frontiers
Understanding Methotrexate - Arthritis Foundation
Understanding Methotrexate  Arthritis Foundation
Is There a Missing Link in Rheumatoid Arthritis Management? - European Medical Journal
Is There a Missing Link in Rheumatoid Arthritis Management?  European Medical Journal
Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY - The Lancet
Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY  The Lancet
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial - Nature
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial  Nature
Editor's Pick: JAK Inhibitors in the Treatment Algorithm of Rheumatoid Arthritis: A Review - European Medical Journal
Editor's Pick: JAK Inhibitors in the Treatment Algorithm of Rheumatoid Arthritis: A Review  European Medical Journal
Rheumatoid arthritis - The Lancet
Rheumatoid arthritis  The Lancet
Foot and Ankle Care in Inflammatory Arthritis - Arthritis Foundation
Foot and Ankle Care in Inflammatory Arthritis  Arthritis Foundation
Rheumatoid Arthritis Life Expectancy: What You Need to Know - HealthCentral
Rheumatoid Arthritis Life Expectancy: What You Need to Know  HealthCentral
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis - The New England Journal of Medicine
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis  The New England Journal of Medicine
Asian and older rheumatoid arthritis sufferers 50% less likely to receive targeted treatment, finds study - Medical Xpress
Asian and older rheumatoid arthritis sufferers 50% less likely to receive targeted treatment, finds study  Medical Xpress
When to Go to the Hospital With Rheumatoid Arthritis Symptoms - HealthCentral
When to Go to the Hospital With Rheumatoid Arthritis Symptoms  HealthCentral
Rheumatoid arthritis diagnosis and management: a clinical update - Nursing Times
Rheumatoid arthritis diagnosis and management: a clinical update  Nursing Times
PsA Takes Longer to Diagnose and Gets Less Early Therapy Than RA - HealthCentral
PsA Takes Longer to Diagnose and Gets Less Early Therapy Than RA  HealthCentral
Improving musculoskeletal care with AI enhanced triage through data driven screening of referral letters - Nature
Improving musculoskeletal care with AI enhanced triage through data driven screening of referral letters  Nature
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment - Nature
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment  Nature
Rheumatoid Arthritis Itching: Causes and Relief - HealthCentral
Rheumatoid Arthritis Itching: Causes and Relief  HealthCentral
Association between obesity and remission in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs | Scientific Reports - Nature
Association between obesity and remission in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs | Scientific Reports  Nature
Are There Natural Remedies for Rheumatoid Arthritis? - Cleveland Clinic Health Essentials
Are There Natural Remedies for Rheumatoid Arthritis?  Cleveland Clinic Health Essentials
Rheumatoid arthritis and baking soda: The potential benefits - MedicalNewsToday
Rheumatoid arthritis and baking soda: The potential benefits  MedicalNewsToday
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission - Nature
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission  Nature
Moderate Psoriatic Arthritis and Perspectives from Phosphodiesterase-4 Inhibition - European Medical Journal
Moderate Psoriatic Arthritis and Perspectives from Phosphodiesterase-4 Inhibition  European Medical Journal
2023 Management Recommendations of Bangladesh Rheumatology Society on Pharmacological Treatment of Rheumatoid Arthritis With Synthetic and Biologic Disease-Modifying Drugs - The Cureus Journal of Medical Science
2023 Management Recommendations of Bangladesh Rheumatology Society on Pharmacological Treatment of Rheumatoid Arthritis With Synthetic and Biologic Disease-Modifying Drugs  The Cureus Journal of Medical Science
Rheumatoid Arthritis in the Wrist: Symptoms, Treatments and More - HealthCentral
Rheumatoid Arthritis in the Wrist: Symptoms, Treatments and More  HealthCentral
Efficacy of B-Cell-Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis - The New England Journal of Medicine
Efficacy of B-Cell-Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis  The New England Journal of Medicine
Therapies for Active Rheumatoid Arthritis after Methotrexate Failure - The New England Journal of Medicine
Therapies for Active Rheumatoid Arthritis after Methotrexate Failure  The New England Journal of Medicine
Professor Appointed to Key Role to Improve Treatment for Rheumatic Conditions | Newswise - Newswise
Professor Appointed to Key Role to Improve Treatment for Rheumatic Conditions | Newswise  Newswise
Palliative care - World Health Organization (WHO)
Palliative care  World Health Organization (WHO)
Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course - Nature
Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course  Nature
Rheumatoid arthritis cure: Is it possible? - MedicalNewsToday
Rheumatoid arthritis cure: Is it possible?  MedicalNewsToday
Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: A randomized, controlled trial - Wiley Online Library
Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: A randomized, controlled trial  Wiley Online Library
UK waiting times for RA and PsA patients: an interview with Dr Marwan Bukhari, Consultant Rheumatologist at the University Hospitals of Morecambe Bay NHS Foundation Trust - News-Medical
UK waiting times for RA and PsA patients: an interview with Dr Marwan Bukhari, Consultant Rheumatologist at the University Hospitals of Morecambe Bay NHS Foundation Trust  News-Medical
Exercises to improve function of the rheumatoid hand (SARAH): a randomised controlled trial - The Lancet
Exercises to improve function of the rheumatoid hand (SARAH): a randomised controlled trial  The Lancet
Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis - Nature
Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis  Nature
Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein CTLA4Ig - The New England Journal of Medicine
Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein CTLA4Ig  The New England Journal of Medicine
Osteoarthritis in primary care: early diagnosis and management - GPonline
Osteoarthritis in primary care: early diagnosis and management  GPonline
Rheumatoid arthritis begins years before symptoms, study finds - MedicalNewsToday
Rheumatoid arthritis begins years before symptoms, study finds  MedicalNewsToday
Rheumatoid arthritis - Nature
Rheumatoid arthritis  Nature
22 natural treatments for psoriatic arthritis - MedicalNewsToday
22 natural treatments for psoriatic arthritis  MedicalNewsToday
Carriers of HLA-DRB1*04:05 have a better clinical response to abatacept in rheumatoid arthritis - Nature
Carriers of HLA-DRB1*04:05 have a better clinical response to abatacept in rheumatoid arthritis  Nature
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients | Scientific Reports - Nature
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients | Scientific Reports  Nature
Psoriatic arthritis: New drug Bimzelx shows promise as treatment - MedicalNewsToday
Psoriatic arthritis: New drug Bimzelx shows promise as treatment  MedicalNewsToday
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics - Nature
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics  Nature
Early intensive treatment of rheumatoid arthritis offers an opportunity to manage fatigue - News-Medical
Early intensive treatment of rheumatoid arthritis offers an opportunity to manage fatigue  News-Medical
What Happens at the First Appointment With a Rheumatologist? - everydayhealth.com
What Happens at the First Appointment With a Rheumatologist?  everydayhealth.com
Early Treatment Boosts Long-term Rheumatoid Arthritis Outcomes - Medscape
Early Treatment Boosts Long-term Rheumatoid Arthritis Outcomes  Medscape
Ibuprofen for arthritis: Is it safe to take every day? - MedicalNewsToday
Ibuprofen for arthritis: Is it safe to take every day?  MedicalNewsToday
Treating rheumatoid arthritis with JAK inhibitors: What to know - MedicalNewsToday
Treating rheumatoid arthritis with JAK inhibitors: What to know  MedicalNewsToday
Rheumatoid arthritis: Early menopause among factors for higher risk - MedicalNewsToday
Rheumatoid arthritis: Early menopause among factors for higher risk  MedicalNewsToday
Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health - Nature
Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health  Nature
Enthesitis Psoriatic Arthritis: Symptoms, Diagnosis, Treatment - HealthCentral
Enthesitis Psoriatic Arthritis: Symptoms, Diagnosis, Treatment  HealthCentral
Turmeric for rheumatoid arthritis: Does it work? - MedicalNewsToday
Turmeric for rheumatoid arthritis: Does it work?  MedicalNewsToday
Weather, seasons, and rheumatoid arthritis flares - MedicalNewsToday
Weather, seasons, and rheumatoid arthritis flares  MedicalNewsToday
Rheumatoid Arthritis: Common Questions About Diagnosis and Management - American Academy of Family Physicians
Rheumatoid Arthritis: Common Questions About Diagnosis and Management  American Academy of Family Physicians
Rheumatoid arthritis severity scale: How it works and outlook - MedicalNewsToday
Rheumatoid arthritis severity scale: How it works and outlook  MedicalNewsToday
Arthritis drug could also help combat ovarian cancer - Nursing Times
Arthritis drug could also help combat ovarian cancer  Nursing Times
Rheumatoid arthritis: Early warning symptoms you must know - Daily Express
Rheumatoid arthritis: Early warning symptoms you must know  Daily Express
Treatments for rheumatoid arthritis: Traditional DMARDS vs. biologics - MedicalNewsToday
Treatments for rheumatoid arthritis: Traditional DMARDS vs. biologics  MedicalNewsToday
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure' - Healio
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure'  Healio
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis - The New England Journal of Medicine
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis  The New England Journal of Medicine
Chinese herbal remedy 'just as effective as methotrexate against arthritis' - MedicalNewsToday
Chinese herbal remedy 'just as effective as methotrexate against arthritis'  MedicalNewsToday
Blood test could provide an early arthritis warning - Nursing Times
Blood test could provide an early arthritis warning  Nursing Times
Ankylosing spondylitis: an update - Royal Australian College of General Practitioners (RACGP)
Ankylosing spondylitis: an update  Royal Australian College of General Practitioners (RACGP)
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis - The New England Journal of Medicine
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis  The New England Journal of Medicine

Articles/peer reviewed publications and
Lay Summaries

  • B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure.
    Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C; PEAC- R4RA investigators. 
    Arthritis Rheumatol. 2019 Nov 29.
    https://doi.org/10.1002/art.41184
    See Lay Summary




The R4-RA trial is funded by the MRC-NIHR Efficacy and
Mechanism Evaluation Programme