Highlights and News

Methotrexate oral or subcutaneous for rheumatoid arthritis (MOOSE): study protocol for a multi-centre randomised trial - BioMed Central
Methotrexate oral or subcutaneous for rheumatoid arthritis (MOOSE): study protocol for a multi-centre randomised trial  BioMed Central
Location and amount of joint involvement differentiates rheumatoid arthritis into different clinical subsets - Nature
Location and amount of joint involvement differentiates rheumatoid arthritis into different clinical subsets  Nature
New gene study offers arthritis treatment insights - HealthandCare.scot
New gene study offers arthritis treatment insights  HealthandCare.scot
New research reveals shared genetic link between endometriosis and immune conditions - University of Oxford
New research reveals shared genetic link between endometriosis and immune conditions  University of Oxford
Is There a Missing Link in Rheumatoid Arthritis Management? - European Medical Journal
Is There a Missing Link in Rheumatoid Arthritis Management?  European Medical Journal
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis - Wiley Online Library
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis  Wiley Online Library
Patients' perception and adherence regarding Methotrexate Autoinjectors for Rheumatoid Arthritis - Ipsos
Patients' perception and adherence regarding Methotrexate Autoinjectors for Rheumatoid Arthritis  Ipsos
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial - The Lancet
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial  The Lancet
Arthritis drug effective in treating sickest COVID-19 patients - Imperial College London
Arthritis drug effective in treating sickest COVID-19 patients  Imperial College London
Rheumatoid arthritis: features, causes and diagnosis - The Pharmaceutical Journal
Rheumatoid arthritis: features, causes and diagnosis  The Pharmaceutical Journal
First UK patient treated in ‘OSCAR' COVID-19 research study, trialling experimental arthritis drug as treatment for coronavirus - Manchester University NHS Foundation Trust
First UK patient treated in ‘OSCAR' COVID-19 research study, trialling experimental arthritis drug as treatment for coronavirus  Manchester University NHS Foundation Trust
Understanding Methotrexate - Arthritis Foundation
Understanding Methotrexate  Arthritis Foundation
The Role of Ultrasound Across the Inflammatory Arthritis Continuum: Focus on "At-Risk” Individuals - Frontiers
The Role of Ultrasound Across the Inflammatory Arthritis Continuum: Focus on "At-Risk” Individuals  Frontiers
Approaches to optimising access to NICE-approved biologic anti-TNFs for patients with rheumatoid arthritis with moderately active disease - bmcmedicine.biomedcentral.com
Approaches to optimising access to NICE-approved biologic anti-TNFs for patients with rheumatoid arthritis with moderately active disease  bmcmedicine.biomedcentral.com
Optimising Response to Advanced Therapies in Rheumatoid Arthritis - Using Prehabilitation to Improve Success? - European Medical Journal
Optimising Response to Advanced Therapies in Rheumatoid Arthritis - Using Prehabilitation to Improve Success?  European Medical Journal
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients - Nature
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients  Nature
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank - Frontiers
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank  Frontiers
Foot and Ankle Care in Inflammatory Arthritis - Arthritis Foundation
Foot and Ankle Care in Inflammatory Arthritis  Arthritis Foundation
Editor's Pick: JAK Inhibitors in the Treatment Algorithm of Rheumatoid Arthritis: A Review - European Medical Journal
Editor's Pick: JAK Inhibitors in the Treatment Algorithm of Rheumatoid Arthritis: A Review  European Medical Journal
Refractory Inflammatory Arthritis definition and model generated through patient and multi-disciplinary professional modified Delphi process - medRxiv
Refractory Inflammatory Arthritis definition and model generated through patient and multi-disciplinary professional modified Delphi process  medRxiv
The 4 Stages of Rheumatoid Arthritis Progression - CreakyJoints
The 4 Stages of Rheumatoid Arthritis Progression  CreakyJoints
Rheumatoid Arthritis Life Expectancy: What You Need to Know - HealthCentral
Rheumatoid Arthritis Life Expectancy: What You Need to Know  HealthCentral
Rheumatoid arthritis: management - The Pharmaceutical Journal
Rheumatoid arthritis: management  The Pharmaceutical Journal
Editor's Pick: JAK Inhibitors in Rheumatoid Arthritis - - European Medical Journal
Editor's Pick: JAK Inhibitors in Rheumatoid Arthritis -  European Medical Journal
Blocking the immune system in rheumatoid arthritis - The Pharmaceutical Journal
Blocking the immune system in rheumatoid arthritis  The Pharmaceutical Journal
Early RA Treatment Can Stave Off Heart Disease - HCPLive
Early RA Treatment Can Stave Off Heart Disease  HCPLive
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment - Nature
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment  Nature
Osteoarthritis - World Health Organization (WHO)
Osteoarthritis  World Health Organization (WHO)
Rheumatoid arthritis diagnosis and management: a clinical update - Nursing Times
Rheumatoid arthritis diagnosis and management: a clinical update  Nursing Times
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission - Nature
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission  Nature
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal - HealthCentral
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal  HealthCentral
Clinical implications of synovial tissue phenotypes in rheumatoid arthritis - Frontiers
Clinical implications of synovial tissue phenotypes in rheumatoid arthritis  Frontiers
Palliative care - World Health Organization (WHO)
Palliative care  World Health Organization (WHO)
Rheumatoid Arthritis - UF Health - University of Florida Health
Rheumatoid Arthritis  UF Health - University of Florida Health
Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course | Scientific Reports - Nature
Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course | Scientific Reports  Nature
Frailty symptoms of rheumatoid arthritis could be reversed, new study shows - STV News
Frailty symptoms of rheumatoid arthritis could be reversed, new study shows  STV News
Gold injections: Can they treat rheumatoid arthritis? - Medical News Today
Gold injections: Can they treat rheumatoid arthritis?  Medical News Today
Association between obesity and remission in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs | Scientific Reports - Nature
Association between obesity and remission in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs | Scientific Reports  Nature
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics - Nature
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics  Nature
Rheumatoid arthritis and baking soda: The potential benefits - Medical News Today
Rheumatoid arthritis and baking soda: The potential benefits  Medical News Today
New drug Bimzelx shows promise as a treatment for psoriatic arthritis - Medical News Today
New drug Bimzelx shows promise as a treatment for psoriatic arthritis  Medical News Today
What Happens at the First Appointment With a Rheumatologist? - Everyday Health
What Happens at the First Appointment With a Rheumatologist?  Everyday Health
Cholesterol Levels and Rheumatoid Arthritis: What's the Link? - HealthCentral
Cholesterol Levels and Rheumatoid Arthritis: What's the Link?  HealthCentral
Rheumatoid arthritis - Nature
Rheumatoid arthritis  Nature
Rheumatoid arthritis: How to spot arthritis bumps - location and size - Daily Express
Rheumatoid arthritis: How to spot arthritis bumps - location and size  Daily Express
2023 Management Recommendations of Bangladesh Rheumatology Society on Pharmacological Treatment of Rheumatoid Arthritis With Synthetic and Biologic Disease-Modifying Drugs - Cureus
2023 Management Recommendations of Bangladesh Rheumatology Society on Pharmacological Treatment of Rheumatoid Arthritis With Synthetic and Biologic Disease-Modifying Drugs  Cureus
AVERT trial demonstrates high rates of DAS-defined remission with Orencia® (abatacept) in combination with Methotrexate in adult patients with early rheumatoid arthritis - Drug Target Review
AVERT trial demonstrates high rates of DAS-defined remission with Orencia® (abatacept) in combination with Methotrexate in adult patients with early rheumatoid arthritis  Drug Target Review
Treating rheumatoid arthritis with JAK inhibitors: What to know - Medical News Today
Treating rheumatoid arthritis with JAK inhibitors: What to know  Medical News Today
Rheumatoid arthritis: Early menopause among factors for higher risk - Medical News Today
Rheumatoid arthritis: Early menopause among factors for higher risk  Medical News Today
Tocilizumab - a new treatment for severe juvenile idiopathic arthritis in children | Research Impact - UCL - University College London
Tocilizumab - a new treatment for severe juvenile idiopathic arthritis in children | Research Impact - UCL  University College London
Rheumatoid arthritis: Do gut bacteria play a role? - Medical News Today
Rheumatoid arthritis: Do gut bacteria play a role?  Medical News Today
Early Treatment Boosts Long-term Rheumatoid Arthritis Outcomes - Medscape
Early Treatment Boosts Long-term Rheumatoid Arthritis Outcomes  Medscape
Osteoarthritis in primary care: early diagnosis and management - GPonline
Osteoarthritis in primary care: early diagnosis and management  GPonline
Early Menopause, Hormone Replacement Therapy May Raise Rheumatoid Arthritis Risk - Healthline
Early Menopause, Hormone Replacement Therapy May Raise Rheumatoid Arthritis Risk  Healthline
Health battle has left beloved TV legend in agony - Metro.co.uk
Health battle has left beloved TV legend in agony  Metro.co.uk
Management of foot ulceration in patients with rheumatoid arthritis - RCNi
Management of foot ulceration in patients with rheumatoid arthritis  RCNi
Arthritis research at UCL | UCL News - UCL - University College London
Arthritis research at UCL | UCL News - UCL  University College London
Pharmaceutical care in rheumatoid arthritis - Hospital Pharmacy Europe
Pharmaceutical care in rheumatoid arthritis  Hospital Pharmacy Europe
Emmerdale legend 'getting his life back' after suffering years of pain - Metro.co.uk
Emmerdale legend 'getting his life back' after suffering years of pain  Metro.co.uk
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis - The New England Journal of Medicine
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis  The New England Journal of Medicine
Blood test could provide an early arthritis warning - Nursing Times
Blood test could provide an early arthritis warning  Nursing Times
Rheumatoid arthritis: Overweight and obese people at greater risk - Daily Express
Rheumatoid arthritis: Overweight and obese people at greater risk  Daily Express
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis - The New England Journal of Medicine
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis  The New England Journal of Medicine
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis - The New England Journal of Medicine
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis  The New England Journal of Medicine
It's not just part of getting old: 7 common myths about arthritis that really aren't helpful - chronicle.gi
It's not just part of getting old: 7 common myths about arthritis that really aren't helpful  chronicle.gi

Articles/peer reviewed publications and
Lay Summaries

  • B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure.
    Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C; PEAC- R4RA investigators. 
    Arthritis Rheumatol. 2019 Nov 29.
    https://doi.org/10.1002/art.41184
    See Lay Summary




The R4-RA trial is funded by the MRC-NIHR Efficacy and
Mechanism Evaluation Programme