Highlights and News

New data reveals ethnic disparities in early rheumatoid arthritis treatment - University of Birmingham
New data reveals ethnic disparities in early rheumatoid arthritis treatment  University of Birmingham
Rheumatoid Arthritis Life Expectancy: What You Need to Know - Health Central
Rheumatoid Arthritis Life Expectancy: What You Need to Know  Health Central
Rheumatoid arthritis - The Lancet
Rheumatoid arthritis  The Lancet
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis - Wiley Online Library
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis  Wiley Online Library
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients - Nature.com
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients  Nature.com
Rheumatoid Arthritis: Autoimmune Joint Inflammation - hss.edu
Rheumatoid Arthritis: Autoimmune Joint Inflammation  hss.edu
Approaches to optimising access to NICE-approved biologic anti-TNFs for patients with rheumatoid arthritis with moderately active disease - BMC Medicine
Approaches to optimising access to NICE-approved biologic anti-TNFs for patients with rheumatoid arthritis with moderately active disease  BMC Medicine
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank - Frontiers
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank  Frontiers
Osteoarthritis - World Health Organization
Osteoarthritis  World Health Organization
11 Signs Your Rheumatoid Arthritis May Be Getting Worse, and You Should See a Doctor - CreakyJoints
11 Signs Your Rheumatoid Arthritis May Be Getting Worse, and You Should See a Doctor  CreakyJoints
Arthritis drug effective in treating sickest COVID-19 patients - Imperial College London
Arthritis drug effective in treating sickest COVID-19 patients  Imperial College London
Rheumatoid arthritis: features, causes and diagnosis - The Pharmaceutical Journal
Rheumatoid arthritis: features, causes and diagnosis  The Pharmaceutical Journal
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial - The Lancet
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial  The Lancet
The 4 Stages of Rheumatoid Arthritis Progression - CreakyJoints
The 4 Stages of Rheumatoid Arthritis Progression  CreakyJoints
Arthritis drugs may reduce mortality and time in ICU for sickest COVID patients - Imperial College London
Arthritis drugs may reduce mortality and time in ICU for sickest COVID patients  Imperial College London
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment - Nature.com
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment  Nature.com
Global, regional, and national burden of rheumatoid arthritis, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021 - The Lancet
Global, regional, and national burden of rheumatoid arthritis, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021  The Lancet
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes - Nature.com
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes  Nature.com
Rheumatoid arthritis - The Lancet
Rheumatoid arthritis  The Lancet
Factors associated with resolution of ultrasound subclinical synovitis in anti-CCP-positive individuals with musculoskeletal symptoms: a UK prospective cohort study - The Lancet
Factors associated with resolution of ultrasound subclinical synovitis in anti-CCP-positive individuals with musculoskeletal symptoms: a UK prospective cohort study  The Lancet
8 Signs of Arthritis You Shouldn't Ignore - AARP
8 Signs of Arthritis You Shouldn't Ignore  AARP
Asian and older rheumatoid arthritis sufferers 50% less likely to receive targeted treatment, finds study - Medical Xpress
Asian and older rheumatoid arthritis sufferers 50% less likely to receive targeted treatment, finds study  Medical Xpress
Adalimumab is found to be a cost-effective treatment for early-stage Dupuytren's disease - Nuffield Department of Population Health
Adalimumab is found to be a cost-effective treatment for early-stage Dupuytren's disease  Nuffield Department of Population Health
Palliative care - World Health Organization
Palliative care  World Health Organization
The Role of Ultrasound Across the Inflammatory Arthritis Continuum: Focus on "At-Risk” Individuals - Frontiers
The Role of Ultrasound Across the Inflammatory Arthritis Continuum: Focus on "At-Risk” Individuals  Frontiers
Signaling pathways in rheumatoid arthritis: implications for targeted therapy - Nature.com
Signaling pathways in rheumatoid arthritis: implications for targeted therapy  Nature.com
The N-Formyl Peptide Receptors and Rheumatoid Arthritis: A Dangerous Liaison or Confusing Relationship? - Frontiers
The N-Formyl Peptide Receptors and Rheumatoid Arthritis: A Dangerous Liaison or Confusing Relationship?  Frontiers
Rheumatoid arthritis - Nature.com
Rheumatoid arthritis  Nature.com
PolyMyalgia Rheumatica treatment with Methotrexate in Optimal Dose in an Early disease phase (PMR MODE): study protocol for a multicenter double-blind placebo controlled trial - Trials Journal
PolyMyalgia Rheumatica treatment with Methotrexate in Optimal Dose in an Early disease phase (PMR MODE): study protocol for a multicenter double-blind placebo controlled trial  Trials Journal
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal - Health Central
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal  Health Central
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission - Nature.com
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission  Nature.com
Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK - The BMJ
Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK  The BMJ
Biological disease‐modifying drugs for rheumatoid arthritis - Chaplin - 2020 - Prescriber - Wiley Online Library
Biological disease‐modifying drugs for rheumatoid arthritis - Chaplin - 2020 - Prescriber  Wiley Online Library
Early Menopause, Hormone Replacement Therapy May Raise Rheumatoid Arthritis Risk - Healthline
Early Menopause, Hormone Replacement Therapy May Raise Rheumatoid Arthritis Risk  Healthline
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis - nejm.org
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis  nejm.org
Blocking the immune system in rheumatoid arthritis - The Pharmaceutical Journal
Blocking the immune system in rheumatoid arthritis  The Pharmaceutical Journal
Cholesterol Levels and Rheumatoid Arthritis: What's the Link? - Health Central
Cholesterol Levels and Rheumatoid Arthritis: What's the Link?  Health Central
Cell detectives offer clues to counter rheumatoid arthritis flare-ups - Lab News
Cell detectives offer clues to counter rheumatoid arthritis flare-ups  Lab News
Treatment to target in rheumatoid arthritis - Nursing Times
Treatment to target in rheumatoid arthritis  Nursing Times
6 Common Questions About Taking Prednisone for Rheumatoid Arthritis - CreakyJoints
6 Common Questions About Taking Prednisone for Rheumatoid Arthritis  CreakyJoints
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics - Nature.com
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics  Nature.com
Rheumatoid arthritis: management - The Pharmaceutical Journal
Rheumatoid arthritis: management  The Pharmaceutical Journal
Identification of novel urinary biomarkers for assessing disease activity and prognosis of rheumatoid arthritis - Nature.com
Identification of novel urinary biomarkers for assessing disease activity and prognosis of rheumatoid arthritis  Nature.com
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients - Nature.com
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients  Nature.com
10 Natural remedies for rheumatoid arthritis - Medical News Today
10 Natural remedies for rheumatoid arthritis  Medical News Today
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure' - Healio
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure'  Healio
Osteoarthritis in primary care: early diagnosis and management - GP online
Osteoarthritis in primary care: early diagnosis and management  GP online
Management of foot ulceration in patients with rheumatoid arthritis - Nursing Standard
Management of foot ulceration in patients with rheumatoid arthritis  Nursing Standard
Characteristic-specific rates of rheumatoid arthritis and its management in Australian general practice - RACGP
Characteristic-specific rates of rheumatoid arthritis and its management in Australian general practice  RACGP
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis - nejm.org
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis  nejm.org
ICD-9-CM codes of rheumatoid arthritis and its variants when rheumatoid arthritis was coded as the main diagnosis a - ResearchGate
ICD-9-CM codes of rheumatoid arthritis and its variants when rheumatoid arthritis was coded as the main diagnosis a  ResearchGate
Rheumatoid arthritis: Overweight and obese people at greater risk - Express
Rheumatoid arthritis: Overweight and obese people at greater risk  Express

Articles/peer reviewed publications and
Lay Summaries

  • B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure.
    Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C; PEAC- R4RA investigators. 
    Arthritis Rheumatol. 2019 Nov 29.
    https://doi.org/10.1002/art.41184
    See Lay Summary




The R4-RA trial is funded by the MRC-NIHR Efficacy and
Mechanism Evaluation Programme