Highlights and News

Why Rheumatoid Arthritis Remission Rates Remain Stagnant - European Medical Journal
Why Rheumatoid Arthritis Remission Rates Remain Stagnant  European Medical Journal
New gene study offers arthritis treatment insights - HealthandCare.scot
New gene study offers arthritis treatment insights  HealthandCare.scot
Rheumatoid arthritis: Pretreatment may delay onset by up to 4 years - Medical News Today
Rheumatoid arthritis: Pretreatment may delay onset by up to 4 years  Medical News Today
New research reveals shared genetic link between endometriosis and immune conditions - University of Oxford
New research reveals shared genetic link between endometriosis and immune conditions  University of Oxford
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis - Wiley Online Library
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis  Wiley Online Library
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial - The Lancet
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial  The Lancet
Rheumatoid arthritis: management - The Pharmaceutical Journal
Rheumatoid arthritis: management  The Pharmaceutical Journal
The 4 Stages of Rheumatoid Arthritis Progression - CreakyJoints
The 4 Stages of Rheumatoid Arthritis Progression  CreakyJoints
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial - Nature
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial  Nature
Frailty may be reversible for some people with rheumatoid arthritis - Medical Xpress
Frailty may be reversible for some people with rheumatoid arthritis  Medical Xpress
When to Go to the Hospital With Rheumatoid Arthritis Symptoms - HealthCentral
When to Go to the Hospital With Rheumatoid Arthritis Symptoms  HealthCentral
Is There a Missing Link in Rheumatoid Arthritis Management? - European Medical Journal
Is There a Missing Link in Rheumatoid Arthritis Management?  European Medical Journal
Referring early arthritis patients within 6 weeks versus 12 weeks after symptom onset: an observational cohort study - The Lancet
Referring early arthritis patients within 6 weeks versus 12 weeks after symptom onset: an observational cohort study  The Lancet
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients - Nature
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients  Nature
Rheumatoid Arthritis in the Wrist: Symptoms, Treatments and More - HealthCentral
Rheumatoid Arthritis in the Wrist: Symptoms, Treatments and More  HealthCentral
Optimising Response to Advanced Therapies in Rheumatoid Arthritis - Using Prehabilitation to Improve Success? - European Medical Journal
Optimising Response to Advanced Therapies in Rheumatoid Arthritis - Using Prehabilitation to Improve Success?  European Medical Journal
Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY - The Lancet
Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY  The Lancet
Editor's Pick: JAK Inhibitors in the Treatment Algorithm of Rheumatoid Arthritis: A Review - European Medical Journal
Editor's Pick: JAK Inhibitors in the Treatment Algorithm of Rheumatoid Arthritis: A Review  European Medical Journal
Rheumatoid arthritis - The Lancet
Rheumatoid arthritis  The Lancet
Editor's Pick: JAK Inhibitors in Rheumatoid Arthritis - - European Medical Journal
Editor's Pick: JAK Inhibitors in Rheumatoid Arthritis -  European Medical Journal
Psoriatic Arthritis: Symptoms, Diagnosis, and Treatment - Arthritis Foundation
Psoriatic Arthritis: Symptoms, Diagnosis, and Treatment  Arthritis Foundation
Rheumatoid arthritis and baking soda: The potential benefits - Medical News Today
Rheumatoid arthritis and baking soda: The potential benefits  Medical News Today
Rheumatoid arthritis - Nature
Rheumatoid arthritis  Nature
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis - The New England Journal of Medicine
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis  The New England Journal of Medicine
Rheumatoid arthritis - The Lancet
Rheumatoid arthritis  The Lancet
Tofacitinib versus Methotrexate in Rheumatoid Arthritis - The New England Journal of Medicine
Tofacitinib versus Methotrexate in Rheumatoid Arthritis  The New England Journal of Medicine
Foot and Ankle Care in Inflammatory Arthritis - Arthritis Foundation
Foot and Ankle Care in Inflammatory Arthritis  Arthritis Foundation
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment | Scientific Reports - Nature
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment | Scientific Reports  Nature
Clinical implications of synovial tissue phenotypes in rheumatoid arthritis - Frontiers
Clinical implications of synovial tissue phenotypes in rheumatoid arthritis  Frontiers
Rheumatoid Arthritis Life Expectancy: What You Need to Know - HealthCentral
Rheumatoid Arthritis Life Expectancy: What You Need to Know  HealthCentral
Asian and older rheumatoid arthritis sufferers 50% less likely to receive targeted treatment, finds study - Medical Xpress
Asian and older rheumatoid arthritis sufferers 50% less likely to receive targeted treatment, finds study  Medical Xpress
Palliative care - World Health Organization (WHO)
Palliative care  World Health Organization (WHO)
Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course - Nature
Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course  Nature
Efficacy of B-Cell-Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis - The New England Journal of Medicine
Efficacy of B-Cell-Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis  The New England Journal of Medicine
Rheumatoid arthritis diagnosis and management: a clinical update - Nursing Times
Rheumatoid arthritis diagnosis and management: a clinical update  Nursing Times
Association between obesity and remission in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs - Nature
Association between obesity and remission in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs  Nature
PsA Takes Longer to Diagnose and Gets Less Early Therapy Than RA - HealthCentral
PsA Takes Longer to Diagnose and Gets Less Early Therapy Than RA  HealthCentral
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission - Nature
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission  Nature
AVERT trial demonstrates high rates of DAS-defined remission with Orencia® (abatacept) in combination with Methotrexate in adult patients with early rheumatoid arthritis - Drug Target Review
AVERT trial demonstrates high rates of DAS-defined remission with Orencia® (abatacept) in combination with Methotrexate in adult patients with early rheumatoid arthritis  Drug Target Review
Exercises to improve function of the rheumatoid hand (SARAH): a randomised controlled trial - The Lancet
Exercises to improve function of the rheumatoid hand (SARAH): a randomised controlled trial  The Lancet
Rheumatoid arthritis: features, causes and diagnosis - The Pharmaceutical Journal
Rheumatoid arthritis: features, causes and diagnosis  The Pharmaceutical Journal
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics - Nature
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics  Nature
Rheumatoid arthritis begins years before symptoms, study finds - Medical News Today
Rheumatoid arthritis begins years before symptoms, study finds  Medical News Today
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients - Nature
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients  Nature
Professor Appointed to Key Role to Improve Treatment for Rheumatic Conditions | Newswise - Newswise
Professor Appointed to Key Role to Improve Treatment for Rheumatic Conditions | Newswise  Newswise
Orthotics for Rheumatoid Arthritis: What to Know - HealthCentral
Orthotics for Rheumatoid Arthritis: What to Know  HealthCentral
Osteoarthritis in primary care: early diagnosis and management - GPonline
Osteoarthritis in primary care: early diagnosis and management  GPonline
Tocilizumab - a new treatment for severe juvenile idiopathic arthritis in children | Research Impact - UCL - University College London
Tocilizumab - a new treatment for severe juvenile idiopathic arthritis in children | Research Impact - UCL  University College London
Early Treatment Boosts Long-term Rheumatoid Arthritis Outcomes - Medscape
Early Treatment Boosts Long-term Rheumatoid Arthritis Outcomes  Medscape
Rheumatoid arthritis: Do gut bacteria play a role? - Medical News Today
Rheumatoid arthritis: Do gut bacteria play a role?  Medical News Today
Psoriatic arthritis: New drug Bimzelx shows promise as treatment - Medical News Today
Psoriatic arthritis: New drug Bimzelx shows promise as treatment  Medical News Today
What Happens at the First Appointment With a Rheumatologist? - Everyday Health
What Happens at the First Appointment With a Rheumatologist?  Everyday Health
Treating rheumatoid arthritis with JAK inhibitors: What to know - Medical News Today
Treating rheumatoid arthritis with JAK inhibitors: What to know  Medical News Today
Rheumatoid arthritis: How to spot arthritis bumps - location and size - Daily Express
Rheumatoid arthritis: How to spot arthritis bumps - location and size  Daily Express
Do you suffer from morning stiffness? It could be a sign of arthritis - Daily Express
Do you suffer from morning stiffness? It could be a sign of arthritis  Daily Express
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis - The New England Journal of Medicine
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis  The New England Journal of Medicine
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis - The New England Journal of Medicine
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis  The New England Journal of Medicine
Blood test could provide an early arthritis warning - Nursing Times
Blood test could provide an early arthritis warning  Nursing Times

Articles/peer reviewed publications and
Lay Summaries

  • B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure.
    Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C; PEAC- R4RA investigators. 
    Arthritis Rheumatol. 2019 Nov 29.
    https://doi.org/10.1002/art.41184
    See Lay Summary




The R4-RA trial is funded by the MRC-NIHR Efficacy and
Mechanism Evaluation Programme