Highlights and News

New data reveals ethnic disparities in early rheumatoid arthritis treatment - University of Birmingham
New data reveals ethnic disparities in early rheumatoid arthritis treatment  University of Birmingham
Asian and older rheumatoid arthritis sufferers 50% less likely to receive targeted treatment, finds study - Medical Xpress
Asian and older rheumatoid arthritis sufferers 50% less likely to receive targeted treatment, finds study  Medical Xpress
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial - The Lancet
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial  The Lancet
Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response - JCI
Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response  JCI
The Role of Ultrasound Across the Inflammatory Arthritis Continuum: Focus on "At-Risk” Individuals - Frontiers
The Role of Ultrasound Across the Inflammatory Arthritis Continuum: Focus on "At-Risk” Individuals  Frontiers
Metabolon and the Scottish Early Rheumatoid Arthritis (SERA) Study Announce Partnership to Leverage Metabolomics Data to Better Understand the Molecular Mechanisms of Rheumatoid Arthritis - PR Newswire
Metabolon and the Scottish Early Rheumatoid Arthritis (SERA) Study Announce Partnership to Leverage Metabolomics Data to Better Understand the Molecular Mechanisms of Rheumatoid Arthritis  PR Newswire
Psoriatic Arthritis in Ankle: Causes, Symptoms, and Treatment - Health Central
Psoriatic Arthritis in Ankle: Causes, Symptoms, and Treatment  Health Central
Strictly's Adam Thomas 'may need medication for life' for chronic illness - Metro.co.uk
Strictly's Adam Thomas 'may need medication for life' for chronic illness  Metro.co.uk
Rheumatoid arthritis - Nature.com
Rheumatoid arthritis  Nature.com
11 Signs Your Rheumatoid Arthritis May Be Getting Worse, and You Should See a Doctor - CreakyJoints
11 Signs Your Rheumatoid Arthritis May Be Getting Worse, and You Should See a Doctor  CreakyJoints
Rheumatoid Arthritis (RA): Practice Essentials, Background, Pathophysiology - Medscape Reference
Rheumatoid Arthritis (RA): Practice Essentials, Background, Pathophysiology  Medscape Reference
Osteoarthritis - World Health Organization
Osteoarthritis  World Health Organization
Arthritis drug effective in treating sickest COVID-19 patients - Imperial College London
Arthritis drug effective in treating sickest COVID-19 patients  Imperial College London
Rheumatoid arthritis diagnosis and management: a clinical update - Nursing Times
Rheumatoid arthritis diagnosis and management: a clinical update  Nursing Times
Rheumatoid arthritis - The Lancet
Rheumatoid arthritis  The Lancet
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients - Nature.com
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients  Nature.com
The 4 Stages of Rheumatoid Arthritis Progression - CreakyJoints
The 4 Stages of Rheumatoid Arthritis Progression  CreakyJoints
Rheumatoid Arthritis Life Expectancy: What You Need to Know - Health Central
Rheumatoid Arthritis Life Expectancy: What You Need to Know  Health Central
Rheumatoid Arthritis X-Ray: Diagnosis and Evaluation - Health Central
Rheumatoid Arthritis X-Ray: Diagnosis and Evaluation  Health Central
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission - Nature.com
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission  Nature.com
Identification of SNPs associated with methotrexate treatment outcomes in patients with early rheumatoid arthritis - Frontiers
Identification of SNPs associated with methotrexate treatment outcomes in patients with early rheumatoid arthritis  Frontiers
Palliative care - World Health Organization
Palliative care  World Health Organization
Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis - nejm.org
Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis  nejm.org
Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis - Nature.com
Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis  Nature.com
Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY - The Lancet
Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY  The Lancet
Arthritis drugs may reduce mortality and time in ICU for sickest COVID patients - Imperial College London
Arthritis drugs may reduce mortality and time in ICU for sickest COVID patients  Imperial College London
Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK - The BMJ
Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK  The BMJ
Bridging Insights From Lymph Node and Synovium Studies in Early Rheumatoid Arthritis - Frontiers
Bridging Insights From Lymph Node and Synovium Studies in Early Rheumatoid Arthritis  Frontiers
What Are Common Symptoms of Autoimmune Disease? - Johns Hopkins Medicine
What Are Common Symptoms of Autoimmune Disease?  Johns Hopkins Medicine
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis - nejm.org
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis  nejm.org
The burden of rheumatoid arthritis in the Middle East and North Africa region, 1990-2019 - Nature.com
The burden of rheumatoid arthritis in the Middle East and North Africa region, 1990-2019  Nature.com
Understanding rheumatoid arthritis at the cellular level - National Institutes of Health
Understanding rheumatoid arthritis at the cellular level  National Institutes of Health
Tight Control of Psoriatic Arthritis: Real-World Outcomes From TICOPA - Rheumatology Advisor
Tight Control of Psoriatic Arthritis: Real-World Outcomes From TICOPA  Rheumatology Advisor
Psoriatic Arthritis and Hip Pain: What You Need to Know - CreakyJoints
Psoriatic Arthritis and Hip Pain: What You Need to Know  CreakyJoints
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal - Health Central
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal  Health Central
Treating rheumatoid arthritis with JAK inhibitors: What to know - Medical News Today
Treating rheumatoid arthritis with JAK inhibitors: What to know  Medical News Today
Epidemiology and clinical characteristics of interstitial lung disease in patients with rheumatoid arthritis from the JointMan database - Nature.com
Epidemiology and clinical characteristics of interstitial lung disease in patients with rheumatoid arthritis from the JointMan database  Nature.com
Blocking the immune system in rheumatoid arthritis - The Pharmaceutical Journal
Blocking the immune system in rheumatoid arthritis  The Pharmaceutical Journal
Clinical trial shows rheumatoid arthritis drug could prevent disease - Medical Xpress
Clinical trial shows rheumatoid arthritis drug could prevent disease  Medical Xpress
AI Efforts Make Strides in Predicting Progression to RA - Medscape
AI Efforts Make Strides in Predicting Progression to RA  Medscape
IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function - Frontiers
IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function  Frontiers
Ultrasound comes up short on early rheumatoid arthritis - AuntMinnie Europe
Ultrasound comes up short on early rheumatoid arthritis  AuntMinnie Europe
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics - Nature.com
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics  Nature.com
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure' - Healio
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure'  Healio
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis - Nature.com
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis  Nature.com
Steroids for Rheumatic Disease and Regional Pain Disorders - MedCentral
Steroids for Rheumatic Disease and Regional Pain Disorders  MedCentral
Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis - Nature.com
Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis  Nature.com
Biological disease‐modifying drugs for rheumatoid arthritis - Chaplin - 2020 - Prescriber - Wiley Online Library
Biological disease‐modifying drugs for rheumatoid arthritis - Chaplin - 2020 - Prescriber  Wiley Online Library
T-cell subset abnormalities predict progression along the Inflammatory Arthritis disease continuum: implications for management - Nature.com
T-cell subset abnormalities predict progression along the Inflammatory Arthritis disease continuum: implications for management  Nature.com
Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein CTLA4Ig - nejm.org
Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein CTLA4Ig  nejm.org
Psoriasis - NHS Website
Psoriasis  NHS Website
10 Natural remedies for rheumatoid arthritis - Medical News Today
10 Natural remedies for rheumatoid arthritis  Medical News Today
UK waiting times for RA and PsA patients: an interview with Dr Marwan Bukhari, Consultant Rheumatologist at the University Hospitals of Morecambe Bay NHS Foundation Trust - News-Medical.Net
UK waiting times for RA and PsA patients: an interview with Dr Marwan Bukhari, Consultant Rheumatologist at the University Hospitals of Morecambe Bay NHS Foundation Trust  News-Medical.Net
Autoimmune Epilepsy | Causes of Seizures - Epilepsy Foundation
Autoimmune Epilepsy | Causes of Seizures  Epilepsy Foundation
Abatacept, Certolizumab: Best Biologics in Early RA? - Medscape
Abatacept, Certolizumab: Best Biologics in Early RA?  Medscape
Low-Dose Prednisone Inclusion in a Methotrexate-Based, Tight Control Strategy for Early Rheumatoid Arthritis: - Annals of Internal Medicine
Low-Dose Prednisone Inclusion in a Methotrexate-Based, Tight Control Strategy for Early Rheumatoid Arthritis:  Annals of Internal Medicine
AVERT trial demonstrates high rates of DAS-defined remission with Orencia® (abatacept) in combination with Methotrexate in adult patients with early rheumatoid arthritis - Drug Target Review
AVERT trial demonstrates high rates of DAS-defined remission with Orencia® (abatacept) in combination with Methotrexate in adult patients with early rheumatoid arthritis  Drug Target Review
Dr Ranj says Strictly will help Adam Thomas long-term health condition - Metro.co.uk
Dr Ranj says Strictly will help Adam Thomas long-term health condition  Metro.co.uk
29 Tips from Podiatrists for Managing Arthritis Pain in Your Feet - CreakyJoints
29 Tips from Podiatrists for Managing Arthritis Pain in Your Feet  CreakyJoints
Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis - Nature.com
Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis  Nature.com
Why old people's illnesses are soaring in youngsters - Daily Mail
Why old people's illnesses are soaring in youngsters  Daily Mail
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients - Nature.com
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients  Nature.com
9 Diseases That Can Mimic Fibromyalgia (and Delay Your Diagnosis) - CreakyJoints
9 Diseases That Can Mimic Fibromyalgia (and Delay Your Diagnosis)  CreakyJoints
Triple Treatment Effective in Early Rheumatoid Arthritis - Medscape
Triple Treatment Effective in Early Rheumatoid Arthritis  Medscape
PUTTING THE SPOTLIGHT ON RHEUMATOID ARTHRITIS - Island Echo
PUTTING THE SPOTLIGHT ON RHEUMATOID ARTHRITIS  Island Echo
Identifying arthritis gene could revolutionise treatment for sufferers - Daily Mail
Identifying arthritis gene could revolutionise treatment for sufferers  Daily Mail
A brief history of ibuprofen - The Pharmaceutical Journal
A brief history of ibuprofen  The Pharmaceutical Journal
Early signs and symptoms of a brain tumor - Medical News Today
Early signs and symptoms of a brain tumor  Medical News Today
What illness does Adam Thomas have? Actor reveals chronic illness diagnosis after secret health battle - Heart
What illness does Adam Thomas have? Actor reveals chronic illness diagnosis after secret health battle  Heart
NICE backs Lilly's JAK inhibitor Olumiant for RA - PharmaTimes
NICE backs Lilly's JAK inhibitor Olumiant for RA  PharmaTimes
Bilateral knee osteoarthritis: Symptoms, diagnosis, and outlook - Medical News Today
Bilateral knee osteoarthritis: Symptoms, diagnosis, and outlook  Medical News Today
U.K. approves anti-inflammatory drugs to treat sickest covid-19 patients after strong results in clinical trial - The Washington Post
U.K. approves anti-inflammatory drugs to treat sickest covid-19 patients after strong results in clinical trial  The Washington Post
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis - nejm.org
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis  nejm.org
Vivian P. Bykerk, BSc, MD, FRCPC - HSS | Hospital for Special Surgery
Vivian P. Bykerk, BSc, MD, FRCPC  HSS | Hospital for Special Surgery
Rheumatoid Arthritis Therapeutics Market Size Report, 2030 - Grand View Research
Rheumatoid Arthritis Therapeutics Market Size Report, 2030  Grand View Research
Thousands of elderly people suffering with rheumatoid arthritis needlessly, say MPs - Daily Mail
Thousands of elderly people suffering with rheumatoid arthritis needlessly, say MPs  Daily Mail
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis - nejm.org
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis  nejm.org

Articles/peer reviewed publications and
Lay Summaries

  • B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure.
    Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C; PEAC- R4RA investigators. 
    Arthritis Rheumatol. 2019 Nov 29.
    https://doi.org/10.1002/art.41184
    See Lay Summary




The R4-RA trial is funded by the MRC-NIHR Efficacy and
Mechanism Evaluation Programme