Highlights and News

New data reveals ethnic disparities in early rheumatoid arthritis treatment - University of Birmingham
New data reveals ethnic disparities in early rheumatoid arthritis treatment  University of Birmingham
Methotrexate-Based Strategies Linked to Lower Infection Risk in Early RA - Medscape
Methotrexate-Based Strategies Linked to Lower Infection Risk in Early RA  Medscape
Inflammatory Arthritis: Rheumatoid, Reactive & Others - HSS | Hospital for Special Surgery
Inflammatory Arthritis: Rheumatoid, Reactive & Others  HSS | Hospital for Special Surgery
Factors associated with biological and targeted synthetic disease-modifying antirheumatic drug initiation for rheumatoid arthritis in underserved patient groups in England and Wales, UK: a national cohort study - The Lancet
Factors associated with biological and targeted synthetic disease-modifying antirheumatic drug initiation for rheumatoid arthritis in underserved patient groups in England and Wales, UK: a national cohort study  The Lancet
Rheumatoid Arthritis Life Expectancy: What You Need to Know - HealthCentral
Rheumatoid Arthritis Life Expectancy: What You Need to Know  HealthCentral
Rheumatoid arthritis: Do gut bacteria play a role? - Medical News Today
Rheumatoid arthritis: Do gut bacteria play a role?  Medical News Today
Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes - ScienceDirect.com
Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes  ScienceDirect.com
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis - Wiley Online Library
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis  Wiley Online Library
Links between arthritis therapy and heart disease improvements - University of Leeds
Links between arthritis therapy and heart disease improvements  University of Leeds
Clinical Trials and Resources - Arthritis Foundation
Clinical Trials and Resources  Arthritis Foundation
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank - Frontiers
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank  Frontiers
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients - Nature
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients  Nature
Arthritis drug effective in treating sickest COVID-19 patients - Imperial College London
Arthritis drug effective in treating sickest COVID-19 patients  Imperial College London
The 4 Stages of Rheumatoid Arthritis Progression - CreakyJoints
The 4 Stages of Rheumatoid Arthritis Progression  CreakyJoints
Rheumatoid arthritis: features, causes and diagnosis - The Pharmaceutical Journal
Rheumatoid arthritis: features, causes and diagnosis  The Pharmaceutical Journal
Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review - BMC Medicine
Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review  BMC Medicine
Tocilizumab: Arthritis drug may treat severe Covid - BBC
Tocilizumab: Arthritis drug may treat severe Covid  BBC
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial - The Lancet
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial  The Lancet
Rheumatoid arthritis - The Lancet
Rheumatoid arthritis  The Lancet
Incidence and management of inflammatory arthritis in England before and during the COVID-19 pandemic: a population-level cohort study using OpenSAFELY - The Lancet
Incidence and management of inflammatory arthritis in England before and during the COVID-19 pandemic: a population-level cohort study using OpenSAFELY  The Lancet
Rheumatoid Arthritis: Autoimmune Joint Inflammation - HSS | Hospital for Special Surgery
Rheumatoid Arthritis: Autoimmune Joint Inflammation  HSS | Hospital for Special Surgery
A multidisciplinary‐led early arthritis service to manage client‐identified participation restrictions in early inflammatory arthritis: A qualitative study of service user and staff perspectives - Codd - 2023 - Musculoskeletal Care - Wiley Online Library
A multidisciplinary‐led early arthritis service to manage client‐identified participation restrictions in early inflammatory arthritis: A qualitative study of service user and staff perspectives - Codd - 2023 - Musculoskeletal Care  Wiley Online Library
RA Remission Rates Vary in England and Wales - Medscape
RA Remission Rates Vary in England and Wales  Medscape
Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials - The Lancet
Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials  The Lancet
Approaches to optimising access to NICE-approved biologic anti-TNFs for patients with rheumatoid arthritis with moderately active disease - BMC Medicine
Approaches to optimising access to NICE-approved biologic anti-TNFs for patients with rheumatoid arthritis with moderately active disease  BMC Medicine
Towards stratified treatment of JIA: machine learning identifies subtypes in response to methotrexate from four UK cohorts - The Lancet
Towards stratified treatment of JIA: machine learning identifies subtypes in response to methotrexate from four UK cohorts  The Lancet
Osteoarthritis - World Health Organization (WHO)
Osteoarthritis  World Health Organization (WHO)
Rheumatoid Arthritis (RA): Practice Essentials, Background, Pathophysiology - Medscape
Rheumatoid Arthritis (RA): Practice Essentials, Background, Pathophysiology  Medscape
Rheumatoid arthritis and baking soda: The potential benefits - Medical News Today
Rheumatoid arthritis and baking soda: The potential benefits  Medical News Today
Gold injections: Can they treat rheumatoid arthritis? - Medical News Today
Gold injections: Can they treat rheumatoid arthritis?  Medical News Today
Rheumatoid arthritis diagnosis and management: a clinical update - Nursing Times
Rheumatoid arthritis diagnosis and management: a clinical update  Nursing Times
Signaling pathways in rheumatoid arthritis: implications for targeted therapy | Signal Transduction and Targeted Therapy - Nature
Signaling pathways in rheumatoid arthritis: implications for targeted therapy | Signal Transduction and Targeted Therapy  Nature
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission - Nature
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission  Nature
Journal of Internal Medicine - Wiley Online Library
Journal of Internal Medicine  Wiley Online Library
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment - Nature
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment  Nature
Angiogenic cytokines can reflect the synovitis severity and treatment response to biologics in rheumatoid arthritis - Nature
Angiogenic cytokines can reflect the synovitis severity and treatment response to biologics in rheumatoid arthritis  Nature
Factors associated with resolution of ultrasound subclinical synovitis in anti-CCP-positive individuals with musculoskeletal symptoms: a UK prospective cohort study - The Lancet
Factors associated with resolution of ultrasound subclinical synovitis in anti-CCP-positive individuals with musculoskeletal symptoms: a UK prospective cohort study  The Lancet
Biological disease‐modifying drugs for rheumatoid arthritis - Chaplin - 2020 - Prescriber - Wiley Online Library
Biological disease‐modifying drugs for rheumatoid arthritis - Chaplin - 2020 - Prescriber  Wiley Online Library
Early Menopause, Hormone Replacement Therapy May Raise Rheumatoid Arthritis Risk - Healthline
Early Menopause, Hormone Replacement Therapy May Raise Rheumatoid Arthritis Risk  Healthline
Blocking the immune system in rheumatoid arthritis - The Pharmaceutical Journal
Blocking the immune system in rheumatoid arthritis  The Pharmaceutical Journal
Rheumatoid arthritis - Nature
Rheumatoid arthritis  Nature
Rheumatoid Lung Disease: Causes, Symptoms, and Treatment Options - HealthCentral
Rheumatoid Lung Disease: Causes, Symptoms, and Treatment Options  HealthCentral
Palliative care - World Health Organization (WHO)
Palliative care  World Health Organization (WHO)
Adalimumab is found to be a cost-effective treatment for early-stage Dupuytren's disease - ndph.ox.ac.uk
Adalimumab is found to be a cost-effective treatment for early-stage Dupuytren's disease  ndph.ox.ac.uk
What Happens at the First Appointment With a Rheumatologist? - Everyday Health
What Happens at the First Appointment With a Rheumatologist?  Everyday Health
Rheumatoid arthritis: Early menopause among factors for higher risk - Medical News Today
Rheumatoid arthritis: Early menopause among factors for higher risk  Medical News Today
Rheumatoid arthritis severity scale: How it works and outlook - Medical News Today
Rheumatoid arthritis severity scale: How it works and outlook  Medical News Today
Rheumatoid arthritis: How to spot arthritis bumps - location and size - Daily Express
Rheumatoid arthritis: How to spot arthritis bumps - location and size  Daily Express
Rheumatoid arthritis: management - The Pharmaceutical Journal
Rheumatoid arthritis: management  The Pharmaceutical Journal
Treating rheumatoid arthritis with JAK inhibitors: What to know - Medical News Today
Treating rheumatoid arthritis with JAK inhibitors: What to know  Medical News Today
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics - Nature
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics  Nature
UK waiting times for RA and PsA patients: an interview with Dr Marwan Bukhari, Consultant Rheumatologist at the University Hospitals of Morecambe Bay NHS Foundation Trust - News-Medical
UK waiting times for RA and PsA patients: an interview with Dr Marwan Bukhari, Consultant Rheumatologist at the University Hospitals of Morecambe Bay NHS Foundation Trust  News-Medical
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure' - Healio
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure'  Healio
8 Signs of Arthritis You Shouldn't Ignore - AARP
8 Signs of Arthritis You Shouldn't Ignore  AARP
Osteoarthritis in primary care: early diagnosis and management - GPonline
Osteoarthritis in primary care: early diagnosis and management  GPonline
10 Natural remedies for rheumatoid arthritis - Medical News Today
10 Natural remedies for rheumatoid arthritis  Medical News Today
Rheumatoid arthritis: Overweight and obese people at greater risk - Daily Express
Rheumatoid arthritis: Overweight and obese people at greater risk  Daily Express
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients - Nature
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients  Nature
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis - The New England Journal of Medicine
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis  The New England Journal of Medicine
COVID-19 headache location: Is headache an early symptom of coronavirus? - Daily Express
COVID-19 headache location: Is headache an early symptom of coronavirus?  Daily Express
A nine-month wait for arthritis treatment: Delays can mean a lifetime of agony for victims - Daily Mail
A nine-month wait for arthritis treatment: Delays can mean a lifetime of agony for victims  Daily Mail
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis - The New England Journal of Medicine
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis  The New England Journal of Medicine

Articles/peer reviewed publications and
Lay Summaries

  • B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure.
    Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C; PEAC- R4RA investigators. 
    Arthritis Rheumatol. 2019 Nov 29.
    https://doi.org/10.1002/art.41184
    See Lay Summary




The R4-RA trial is funded by the MRC-NIHR Efficacy and
Mechanism Evaluation Programme