Highlights and News

New data reveals ethnic disparities in early rheumatoid arthritis treatment - University of Birmingham
New data reveals ethnic disparities in early rheumatoid arthritis treatment  University of Birmingham
Rheumatoid Arthritis Life Expectancy: What You Need to Know - Health Central
Rheumatoid Arthritis Life Expectancy: What You Need to Know  Health Central
Asian and older rheumatoid arthritis sufferers 50% less likely to receive targeted treatment, finds study - Medical Xpress
Asian and older rheumatoid arthritis sufferers 50% less likely to receive targeted treatment, finds study  Medical Xpress
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial - The Lancet
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial  The Lancet
Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response - JCI
Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response  JCI
Rheumatoid arthritis - Nature.com
Rheumatoid arthritis  Nature.com
11 Signs Your Rheumatoid Arthritis May Be Getting Worse, and You Should See a Doctor - CreakyJoints
11 Signs Your Rheumatoid Arthritis May Be Getting Worse, and You Should See a Doctor  CreakyJoints
Psoriatic Arthritis in Ankle: Causes, Symptoms, and Treatment - Health Central
Psoriatic Arthritis in Ankle: Causes, Symptoms, and Treatment  Health Central
Arthritis drug effective in treating sickest COVID-19 patients - Imperial College London
Arthritis drug effective in treating sickest COVID-19 patients  Imperial College London
Rheumatoid arthritis: features, causes and diagnosis - The Pharmaceutical Journal
Rheumatoid arthritis: features, causes and diagnosis  The Pharmaceutical Journal
Osteoarthritis - World Health Organization
Osteoarthritis  World Health Organization
Cell detectives offer clues to counter rheumatoid arthritis flare-ups - Lab News
Cell detectives offer clues to counter rheumatoid arthritis flare-ups  Lab News
Rheumatoid arthritis diagnosis and management: a clinical update - Nursing Times
Rheumatoid arthritis diagnosis and management: a clinical update  Nursing Times
Rheumatoid arthritis - The Lancet
Rheumatoid arthritis  The Lancet
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients - Nature.com
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients  Nature.com
The 4 Stages of Rheumatoid Arthritis Progression - CreakyJoints
The 4 Stages of Rheumatoid Arthritis Progression  CreakyJoints
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes - Nature.com
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes  Nature.com
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial - Nature.com
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial  Nature.com
Signaling pathways in rheumatoid arthritis: implications for targeted therapy - Nature.com
Signaling pathways in rheumatoid arthritis: implications for targeted therapy  Nature.com
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission - Nature.com
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission  Nature.com
Identification of SNPs associated with methotrexate treatment outcomes in patients with early rheumatoid arthritis - Frontiers
Identification of SNPs associated with methotrexate treatment outcomes in patients with early rheumatoid arthritis  Frontiers
Treatment to target in rheumatoid arthritis - Nursing Times
Treatment to target in rheumatoid arthritis  Nursing Times
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment - Nature.com
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment  Nature.com
Adalimumab is found to be a cost-effective treatment for early-stage Dupuytren's disease - Nuffield Department of Population Health
Adalimumab is found to be a cost-effective treatment for early-stage Dupuytren's disease  Nuffield Department of Population Health
Arthritis drugs may reduce mortality and time in ICU for sickest COVID patients - Imperial College London
Arthritis drugs may reduce mortality and time in ICU for sickest COVID patients  Imperial College London
Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY - The Lancet
Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY  The Lancet
Rheumatoid Arthritis X-Ray: Diagnosis and Evaluation - Health Central
Rheumatoid Arthritis X-Ray: Diagnosis and Evaluation  Health Central
Bridging Insights From Lymph Node and Synovium Studies in Early Rheumatoid Arthritis - Frontiers
Bridging Insights From Lymph Node and Synovium Studies in Early Rheumatoid Arthritis  Frontiers
Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK - The BMJ
Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK  The BMJ
Frailty common in rheumatoid arthritis, predicts mortality, hospitalization - Healio
Frailty common in rheumatoid arthritis, predicts mortality, hospitalization  Healio
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis - nejm.org
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis  nejm.org
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal - Health Central
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal  Health Central
Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis - nejm.org
Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis  nejm.org
Palliative care - World Health Organization
Palliative care  World Health Organization
Blocking the immune system in rheumatoid arthritis - The Pharmaceutical Journal
Blocking the immune system in rheumatoid arthritis  The Pharmaceutical Journal
What Are Common Symptoms of Autoimmune Disease? - Johns Hopkins Medicine
What Are Common Symptoms of Autoimmune Disease?  Johns Hopkins Medicine
Understanding rheumatoid arthritis at the cellular level - National Institutes of Health
Understanding rheumatoid arthritis at the cellular level  National Institutes of Health
Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol - Trials Journal
Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol  Trials Journal
Failure to warn: Hundreds died while taking an arthritis drug, but nobody alerted patients - STAT
Failure to warn: Hundreds died while taking an arthritis drug, but nobody alerted patients  STAT
Rheumatoid arthritis: management - The Pharmaceutical Journal
Rheumatoid arthritis: management  The Pharmaceutical Journal
Epidemiology and clinical characteristics of interstitial lung disease in patients with rheumatoid arthritis from the JointMan database - Nature.com
Epidemiology and clinical characteristics of interstitial lung disease in patients with rheumatoid arthritis from the JointMan database  Nature.com
Biological disease‐modifying drugs for rheumatoid arthritis - Chaplin - 2020 - Prescriber - Wiley Online Library
Biological disease‐modifying drugs for rheumatoid arthritis - Chaplin - 2020 - Prescriber  Wiley Online Library
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics - Nature.com
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics  Nature.com
Treating rheumatoid arthritis with JAK inhibitors: What to know - Medical News Today
Treating rheumatoid arthritis with JAK inhibitors: What to know  Medical News Today
IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function - Frontiers
IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function  Frontiers
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis - Nature.com
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis  Nature.com
First UK patient given GSK's experimental arthritis drug in COVID-19 trial - PharmaTimes
First UK patient given GSK's experimental arthritis drug in COVID-19 trial  PharmaTimes
Hammersmith Hospital - Imperial College Healthcare NHS Trust
Hammersmith Hospital  Imperial College Healthcare NHS Trust
Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis - Nature.com
Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis  Nature.com
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure' - Healio
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure'  Healio
My job left me unable to dress myself. Then I got news no 21-year-old dreams of - Metro.co.uk
My job left me unable to dress myself. Then I got news no 21-year-old dreams of  Metro.co.uk
Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein CTLA4Ig - nejm.org
Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein CTLA4Ig  nejm.org
AVERT trial demonstrates high rates of DAS-defined remission with Orencia® (abatacept) in combination with Methotrexate in adult patients with early rheumatoid arthritis - Drug Target Review
AVERT trial demonstrates high rates of DAS-defined remission with Orencia® (abatacept) in combination with Methotrexate in adult patients with early rheumatoid arthritis  Drug Target Review
Low-Dose Prednisone Inclusion in a Methotrexate-Based, Tight Control Strategy for Early Rheumatoid Arthritis: - Annals of Internal Medicine
Low-Dose Prednisone Inclusion in a Methotrexate-Based, Tight Control Strategy for Early Rheumatoid Arthritis:  Annals of Internal Medicine
10 Natural remedies for rheumatoid arthritis - Medical News Today
10 Natural remedies for rheumatoid arthritis  Medical News Today
Identification of novel urinary biomarkers for assessing disease activity and prognosis of rheumatoid arthritis - Nature.com
Identification of novel urinary biomarkers for assessing disease activity and prognosis of rheumatoid arthritis  Nature.com
29 Tips from Podiatrists for Managing Arthritis Pain in Your Feet - CreakyJoints
29 Tips from Podiatrists for Managing Arthritis Pain in Your Feet  CreakyJoints
Strictly's Adam Thomas opens up about chronic illness diagnosis - Metro.co.uk
Strictly's Adam Thomas opens up about chronic illness diagnosis  Metro.co.uk
Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health - Nature.com
Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health  Nature.com
Strictly's Adam Thomas 'may need medication for life' for chronic illness - Metro.co.uk
Strictly's Adam Thomas 'may need medication for life' for chronic illness  Metro.co.uk
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients - Nature.com
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients  Nature.com
Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis - Nature.com
Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis  Nature.com
What illness does Adam Thomas have? Actor reveals chronic illness diagnosis after secret health battle - Heart
What illness does Adam Thomas have? Actor reveals chronic illness diagnosis after secret health battle  Heart
PUTTING THE SPOTLIGHT ON RHEUMATOID ARTHRITIS - Island Echo
PUTTING THE SPOTLIGHT ON RHEUMATOID ARTHRITIS  Island Echo
Bilateral knee osteoarthritis: Symptoms, diagnosis, and outlook - Medical News Today
Bilateral knee osteoarthritis: Symptoms, diagnosis, and outlook  Medical News Today
What do Shingles Look Like? Pictures and More - Healthline
What do Shingles Look Like? Pictures and More  Healthline
Thousands of elderly people suffering with rheumatoid arthritis needlessly, say MPs - Daily Mail
Thousands of elderly people suffering with rheumatoid arthritis needlessly, say MPs  Daily Mail
Vivian P. Bykerk, BSc, MD, FRCPC - HSS | Hospital for Special Surgery
Vivian P. Bykerk, BSc, MD, FRCPC  HSS | Hospital for Special Surgery
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis - nejm.org
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis  nejm.org
Tom Selleck health: Blue Bloods star 'falling apart'- concerns for actor's health - Express
Tom Selleck health: Blue Bloods star 'falling apart'- concerns for actor's health  Express
Characteristic-specific rates of rheumatoid arthritis and its management in Australian general practice - RACGP
Characteristic-specific rates of rheumatoid arthritis and its management in Australian general practice  RACGP
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis - nejm.org
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis  nejm.org

Articles/peer reviewed publications and
Lay Summaries

  • B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure.
    Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C; PEAC- R4RA investigators. 
    Arthritis Rheumatol. 2019 Nov 29.
    https://doi.org/10.1002/art.41184
    See Lay Summary




The R4-RA trial is funded by the MRC-NIHR Efficacy and
Mechanism Evaluation Programme