Highlights and News

New data reveals ethnic disparities in early rheumatoid arthritis treatment - University of Birmingham
New data reveals ethnic disparities in early rheumatoid arthritis treatment  University of Birmingham
Factors associated with biological and targeted synthetic disease-modifying antirheumatic drug initiation for rheumatoid arthritis in underserved patient groups in England and Wales, UK: a national cohort study - The Lancet
Factors associated with biological and targeted synthetic disease-modifying antirheumatic drug initiation for rheumatoid arthritis in underserved patient groups in England and Wales, UK: a national cohort study  The Lancet
Rheumatoid Arthritis Life Expectancy: What You Need to Know - HealthCentral
Rheumatoid Arthritis Life Expectancy: What You Need to Know  HealthCentral
Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes - ScienceDirect.com
Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes  ScienceDirect.com
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis - Wiley Online Library
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis  Wiley Online Library
Clinical Trials and Resources - Arthritis Foundation
Clinical Trials and Resources  Arthritis Foundation
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank - Frontiers
Impact of Rheumatoid Arthritis and Its Management on Falls, Fracture and Bone Mineral Density in UK Biobank  Frontiers
Rheumatoid Arthritis: Autoimmune Joint Inflammation - HSS | Hospital for Special Surgery
Rheumatoid Arthritis: Autoimmune Joint Inflammation  HSS | Hospital for Special Surgery
11 Signs Your Rheumatoid Arthritis May Be Getting Worse, and You Should See a Doctor - CreakyJoints
11 Signs Your Rheumatoid Arthritis May Be Getting Worse, and You Should See a Doctor  CreakyJoints
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients - Nature
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients  Nature
Rheumatoid arthritis: features, causes and diagnosis - The Pharmaceutical Journal
Rheumatoid arthritis: features, causes and diagnosis  The Pharmaceutical Journal
Arthritis drug effective in treating sickest COVID-19 patients - Imperial College London
Arthritis drug effective in treating sickest COVID-19 patients  Imperial College London
Osteoarthritis - World Health Organization (WHO)
Osteoarthritis  World Health Organization (WHO)
Rheumatoid arthritis and socioeconomic status: a need to address SES in the UK - Clinical Trials Arena
Rheumatoid arthritis and socioeconomic status: a need to address SES in the UK  Clinical Trials Arena
Approaches to optimising access to NICE-approved biologic anti-TNFs for patients with rheumatoid arthritis with moderately active disease - BMC Medicine
Approaches to optimising access to NICE-approved biologic anti-TNFs for patients with rheumatoid arthritis with moderately active disease  BMC Medicine
Rheumatoid arthritis - The Lancet
Rheumatoid arthritis  The Lancet
The 4 Stages of Rheumatoid Arthritis Progression - CreakyJoints
The 4 Stages of Rheumatoid Arthritis Progression  CreakyJoints
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial - The Lancet
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial  The Lancet
Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials - The Lancet
Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials  The Lancet
Towards stratified treatment of JIA: machine learning identifies subtypes in response to methotrexate from four UK cohorts - The Lancet
Towards stratified treatment of JIA: machine learning identifies subtypes in response to methotrexate from four UK cohorts  The Lancet
Asian and older rheumatoid arthritis sufferers 50% less likely to receive targeted treatment, finds study - Medical Xpress
Asian and older rheumatoid arthritis sufferers 50% less likely to receive targeted treatment, finds study  Medical Xpress
Rheumatology - Northumbria Healthcare NHS Foundation Trust
Rheumatology  Northumbria Healthcare NHS Foundation Trust
Rheumatoid arthritis diagnosis and management: a clinical update - nursingtimes.net
Rheumatoid arthritis diagnosis and management: a clinical update  nursingtimes.net
Signaling pathways in rheumatoid arthritis: implications for targeted therapy | Signal Transduction and Targeted Therapy - Nature
Signaling pathways in rheumatoid arthritis: implications for targeted therapy | Signal Transduction and Targeted Therapy  Nature
The Role of Ultrasound Across the Inflammatory Arthritis Continuum: Focus on "At-Risk” Individuals - Frontiers
The Role of Ultrasound Across the Inflammatory Arthritis Continuum: Focus on "At-Risk” Individuals  Frontiers
The N-Formyl Peptide Receptors and Rheumatoid Arthritis: A Dangerous Liaison or Confusing Relationship? - Frontiers
The N-Formyl Peptide Receptors and Rheumatoid Arthritis: A Dangerous Liaison or Confusing Relationship?  Frontiers
Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK - The BMJ
Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK  The BMJ
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes - Nature
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes  Nature
Adalimumab is found to be a cost-effective treatment for early-stage Dupuytren's disease - ndph.ox.ac.uk
Adalimumab is found to be a cost-effective treatment for early-stage Dupuytren's disease  ndph.ox.ac.uk
Early Menopause, Hormone Replacement Therapy May Raise Rheumatoid Arthritis Risk - Healthline
Early Menopause, Hormone Replacement Therapy May Raise Rheumatoid Arthritis Risk  Healthline
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal - HealthCentral
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal  HealthCentral
Factors associated with resolution of ultrasound subclinical synovitis in anti-CCP-positive individuals with musculoskeletal symptoms: a UK prospective cohort study - The Lancet
Factors associated with resolution of ultrasound subclinical synovitis in anti-CCP-positive individuals with musculoskeletal symptoms: a UK prospective cohort study  The Lancet
Cholesterol Levels and Rheumatoid Arthritis: What's the Link? - HealthCentral
Cholesterol Levels and Rheumatoid Arthritis: What's the Link?  HealthCentral
Rheumatoid arthritis - Nature
Rheumatoid arthritis  Nature
Rheumatoid Arthritis X-Ray: Diagnosis and Evaluation - HealthCentral
Rheumatoid Arthritis X-Ray: Diagnosis and Evaluation  HealthCentral
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission - Nature
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission  Nature
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment - Nature
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment  Nature
Biological disease‐modifying drugs for rheumatoid arthritis - Chaplin - 2020 - Prescriber - Wiley Online Library
Biological disease‐modifying drugs for rheumatoid arthritis - Chaplin - 2020 - Prescriber  Wiley Online Library
Blocking the immune system in rheumatoid arthritis - The Pharmaceutical Journal
Blocking the immune system in rheumatoid arthritis  The Pharmaceutical Journal
6 Common Questions About Taking Prednisone for Rheumatoid Arthritis - CreakyJoints
6 Common Questions About Taking Prednisone for Rheumatoid Arthritis  CreakyJoints
Palliative care - World Health Organization (WHO)
Palliative care  World Health Organization (WHO)
8 Signs of Arthritis You Shouldn't Ignore - AARP
8 Signs of Arthritis You Shouldn't Ignore  AARP
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics - Nature
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics  Nature
Identification of novel urinary biomarkers for assessing disease activity and prognosis of rheumatoid arthritis - Nature
Identification of novel urinary biomarkers for assessing disease activity and prognosis of rheumatoid arthritis  Nature
Cancer Q&A: Our health experts answer your questions on early signs, testing, treatments and more - The Telegraph
Cancer Q&A: Our health experts answer your questions on early signs, testing, treatments and more  The Telegraph
Rheumatoid arthritis: How to spot arthritis bumps - location and size - Daily Express
Rheumatoid arthritis: How to spot arthritis bumps - location and size  Daily Express
Rheumatoid arthritis: management - The Pharmaceutical Journal
Rheumatoid arthritis: management  The Pharmaceutical Journal
10 Natural remedies for rheumatoid arthritis - Medical News Today
10 Natural remedies for rheumatoid arthritis  Medical News Today
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure' - Healio
CAR T-cell therapy may be a ‘miracle,' but it is too soon to say ‘cure'  Healio
Rheumatoid arthritis: Overweight and obese people at greater risk - Daily Express
Rheumatoid arthritis: Overweight and obese people at greater risk  Daily Express
Osteoarthritis in primary care: early diagnosis and management - GPonline
Osteoarthritis in primary care: early diagnosis and management  GPonline
Early Treatment Improves Rheumatoid Arthritis Symptoms, Helps Patients Live Longer, Study Suggests - rheumatoidarthritisnews.com
Early Treatment Improves Rheumatoid Arthritis Symptoms, Helps Patients Live Longer, Study Suggests  rheumatoidarthritisnews.com
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis - The New England Journal of Medicine
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis  The New England Journal of Medicine
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis - The New England Journal of Medicine
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis  The New England Journal of Medicine

Articles/peer reviewed publications and
Lay Summaries

  • B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure.
    Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C; PEAC- R4RA investigators. 
    Arthritis Rheumatol. 2019 Nov 29.
    https://doi.org/10.1002/art.41184
    See Lay Summary




The R4-RA trial is funded by the MRC-NIHR Efficacy and
Mechanism Evaluation Programme