Highlights and News

Leeds leads global trial of groundbreaking cell therapy for autoimmune diseases - National Health Executive
Leeds leads global trial of groundbreaking cell therapy for autoimmune diseases  National Health Executive
Rheumatoid arthritis patient trial backs up vaccination advantages of methotrexate delay - The Pharmacist
Rheumatoid arthritis patient trial backs up vaccination advantages of methotrexate delay  The Pharmacist
PEPITEM Regulates the Synovial Microenvironment During Immune-Mediated Inflammatory Arthritis to Limit Disease - Wiley & Sons
PEPITEM Regulates the Synovial Microenvironment During Immune-Mediated Inflammatory Arthritis to Limit Disease  Wiley & Sons
Review of the European Alliance of Associations for Rheumatology (EULAR) 2026 Congress - EMJ
Review of the European Alliance of Associations for Rheumatology (EULAR) 2026 Congress  EMJ
Investigating the Impact of Sex on Outcomes in Juvenile Idiopathic Arthritis - medRxiv
Investigating the Impact of Sex on Outcomes in Juvenile Idiopathic Arthritis  medRxiv
Why Rheumatoid Arthritis Remission Rates Remain Stagnant - European Medical Journal
Why Rheumatoid Arthritis Remission Rates Remain Stagnant  European Medical Journal
Promising Early Safety Data as Quell Therapeutics Advances - GlobeNewswire
Promising Early Safety Data as Quell Therapeutics Advances  GlobeNewswire
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients - Nature
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients  Nature
8 Diseases That Could Mimic Rheumatoid Arthritis - and Delay Your Diagnosis - CreakyJoints
8 Diseases That Could Mimic Rheumatoid Arthritis - and Delay Your Diagnosis  CreakyJoints
Foot and Ankle Care in Inflammatory Arthritis - Arthritis Foundation
Foot and Ankle Care in Inflammatory Arthritis  Arthritis Foundation
Championing physio for inflammatory arthritis - The Chartered Society of Physiotherapy
Championing physio for inflammatory arthritis  The Chartered Society of Physiotherapy
New gene study offers arthritis treatment insights - HealthandCare.scot
New gene study offers arthritis treatment insights  HealthandCare.scot
‘Milestone' as NICE recommends biologics in moderate rheumatoid arthritis for the first time - The Pharmaceutical Journal
‘Milestone' as NICE recommends biologics in moderate rheumatoid arthritis for the first time  The Pharmaceutical Journal
Undifferentiated Arthritis: Identifying Candidates for Early Treatment to Prevent Progression to RA - Rheumatology Advisor
Undifferentiated Arthritis: Identifying Candidates for Early Treatment to Prevent Progression to RA  Rheumatology Advisor
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis - Wiley Online Library
Nurse-led care for people with early rheumatoid arthritis: Interview study with thematic analysis  Wiley Online Library
Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis - Nature
Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis  Nature
Using Polygenic Risk Scores to Aid Diagnosis of Patients With Early Inflammatory Arthritis: Results From the Norfolk Arthritis Register - Wiley & Sons
Using Polygenic Risk Scores to Aid Diagnosis of Patients With Early Inflammatory Arthritis: Results From the Norfolk Arthritis Register  Wiley & Sons
Editor's Pick: JAK Inhibitors in the Treatment Algorithm of Rheumatoid Arthritis: A Review - EMJ
Editor's Pick: JAK Inhibitors in the Treatment Algorithm of Rheumatoid Arthritis: A Review  EMJ
Identification, Monitoring, and Management of Rheumatoid Arthritis-Associated Interstitial Lung Disease - Wiley & Sons
Identification, Monitoring, and Management of Rheumatoid Arthritis-Associated Interstitial Lung Disease  Wiley & Sons
Is There a Missing Link in Rheumatoid Arthritis Management? - EMJ
Is There a Missing Link in Rheumatoid Arthritis Management?  EMJ
Crying out for equity: outcomes of rheumatic diseases confounded by ethnicity | Clinical Rheumatology - Springer Nature Link
Crying out for equity: outcomes of rheumatic diseases confounded by ethnicity | Clinical Rheumatology  Springer Nature Link
Early menopause and HRT among hormonal factors linked to heightened rheumatoid arthritis risk - BMJ Group
Early menopause and HRT among hormonal factors linked to heightened rheumatoid arthritis risk  BMJ Group
Are There Natural Remedies for Rheumatoid Arthritis? - Cleveland Clinic Health Essentials
Are There Natural Remedies for Rheumatoid Arthritis?  Cleveland Clinic Health Essentials
Trial suggests JAK1 inhibitor is superior to methotrexate for treatment of early rheumatoid arthritis - The Pharmaceutical Journal
Trial suggests JAK1 inhibitor is superior to methotrexate for treatment of early rheumatoid arthritis  The Pharmaceutical Journal
Tight Control of Psoriatic Arthritis: Real-World Outcomes From TICOPA - Rheumatology Advisor
Tight Control of Psoriatic Arthritis: Real-World Outcomes From TICOPA  Rheumatology Advisor
PsA Takes Longer to Diagnose and Gets Less Early Therapy Than RA - HealthCentral
PsA Takes Longer to Diagnose and Gets Less Early Therapy Than RA  HealthCentral
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis - NEJM
Sustained Remission with Etanercept Tapering in Early Rheumatoid Arthritis  NEJM
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics | Scientific Reports - Nature
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics | Scientific Reports  Nature
Blocking the immune system in rheumatoid arthritis - The Pharmaceutical Journal
Blocking the immune system in rheumatoid arthritis  The Pharmaceutical Journal
7 Diseases That Can Mimic Psoriatic Arthritis - and Delay Your Diagnosis - CreakyJoints
7 Diseases That Can Mimic Psoriatic Arthritis - and Delay Your Diagnosis  CreakyJoints
Artificial intelligence in rheumatoid arthritis research: A bibliometric analysis from 2004 to 2023 - Wiley Online Library
Artificial intelligence in rheumatoid arthritis research: A bibliometric analysis from 2004 to 2023  Wiley Online Library
COPD: A Major Predictor of Early Mortality in Rheumatoid Arthritis - Rheumatology Advisor
COPD: A Major Predictor of Early Mortality in Rheumatoid Arthritis  Rheumatology Advisor
Rheumatoid arthritis diagnosis and management: a clinical update - Nursing Times
Rheumatoid arthritis diagnosis and management: a clinical update  Nursing Times
Therapies for Active Rheumatoid Arthritis after Methotrexate Failure - NEJM
Therapies for Active Rheumatoid Arthritis after Methotrexate Failure  NEJM
Psoriatic Arthritis in the Ankle: Could Your Ankle Pain Be a Sign of Psoriatic Arthritis? - CreakyJoints
Psoriatic Arthritis in the Ankle: Could Your Ankle Pain Be a Sign of Psoriatic Arthritis?  CreakyJoints
Moderate Psoriatic Arthritis and Perspectives from Phosphodiesterase-4 Inhibition - EMJ
Moderate Psoriatic Arthritis and Perspectives from Phosphodiesterase-4 Inhibition  EMJ
Addressing the rheumatic disease diagnostic gap via the lab - Laboratory News
Addressing the rheumatic disease diagnostic gap via the lab  Laboratory News
Rheumatoid arthritis - Nature
Rheumatoid arthritis  Nature
Meera Alagarajah on dealing with rheumatoid arthritis - Dentistry Online - Dentistry UK
Meera Alagarajah on dealing with rheumatoid arthritis - Dentistry Online  Dentistry UK
Arthritis drug shows potential in skin cancer - PharmaTimes
Arthritis drug shows potential in skin cancer  PharmaTimes
Rheumatoid arthritis begins years before symptoms, study finds - Medical News Today
Rheumatoid arthritis begins years before symptoms, study finds  Medical News Today
Quell launches chill phase 1/2 trial for novel cartreg therapy - PharmaTimes
Quell launches chill phase 1/2 trial for novel cartreg therapy  PharmaTimes
Integrating point-of-care ultrasound into rheumatology practice - Medycyna Praktyczna
Integrating point-of-care ultrasound into rheumatology practice  Medycyna Praktyczna
Ibuprofen for arthritis: Is it safe to take every day? - Medical News Today
Ibuprofen for arthritis: Is it safe to take every day?  Medical News Today
The breakthrough that could stop arthritis and diabetes in their tracks - The i Paper
The breakthrough that could stop arthritis and diabetes in their tracks  The i Paper
PEPITEM 'replacement therapy' shows potential for early-stage inflammatory arthritis - Medical Xpress
PEPITEM 'replacement therapy' shows potential for early-stage inflammatory arthritis  Medical Xpress
Clinical Review - Rheumatoid arthritis - GPonline
Clinical Review - Rheumatoid arthritis  GPonline
Rheumatoid Arthritis: Common Questions About Diagnosis and Management - American Academy Of Family Physicians | AAFP
Rheumatoid Arthritis: Common Questions About Diagnosis and Management  American Academy Of Family Physicians | AAFP
Minocycline for rheumatoid arthritis: What to know - Medical News Today
Minocycline for rheumatoid arthritis: What to know  Medical News Today
Turmeric for rheumatoid arthritis: Does it work? - Medical News Today
Turmeric for rheumatoid arthritis: Does it work?  Medical News Today
Treating rheumatoid arthritis with JAK inhibitors: What to know - MedicalNewsToday
Treating rheumatoid arthritis with JAK inhibitors: What to know  MedicalNewsToday
22 natural treatments for psoriatic arthritis - Medical News Today
22 natural treatments for psoriatic arthritis  Medical News Today
Weather, seasons, and rheumatoid arthritis flares - Medical News Today
Weather, seasons, and rheumatoid arthritis flares  Medical News Today
New drug Bimzelx shows promise as a treatment for psoriatic arthritis - Medical News Today
New drug Bimzelx shows promise as a treatment for psoriatic arthritis  Medical News Today
What to know about rheumatoid arthritis and intermittent fasting - Medical News Today
What to know about rheumatoid arthritis and intermittent fasting  Medical News Today
Treatments for rheumatoid arthritis: Traditional DMARDS vs. biologics - MedicalNewsToday
Treatments for rheumatoid arthritis: Traditional DMARDS vs. biologics  MedicalNewsToday
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis - NEJM
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis  NEJM
Ankylosing spondylitis: an update - Royal Australian College of General Practitioners (RACGP)
Ankylosing spondylitis: an update  Royal Australian College of General Practitioners (RACGP)
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis - NEJM
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis  NEJM
England | London | Six taken ill after drug trials - BBC
England | London | Six taken ill after drug trials  BBC

Articles/peer reviewed publications and
Lay Summaries

  • B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure.
    Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C; PEAC- R4RA investigators. 
    Arthritis Rheumatol. 2019 Nov 29.
    https://doi.org/10.1002/art.41184
    See Lay Summary




The R4-RA trial is funded by the MRC-NIHR Efficacy and
Mechanism Evaluation Programme