Highlights and News

New data reveals ethnic disparities in early rheumatoid arthritis treatment - University of Birmingham
New data reveals ethnic disparities in early rheumatoid arthritis treatment  University of Birmingham
Rheumatoid Arthritis Life Expectancy: What You Need to Know - Health Central
Rheumatoid Arthritis Life Expectancy: What You Need to Know  Health Central
Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response - JCI
Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response  JCI
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial - The Lancet
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial  The Lancet
Rheumatoid arthritis - Nature.com
Rheumatoid arthritis  Nature.com
The 4 Stages of Rheumatoid Arthritis Progression - CreakyJoints
The 4 Stages of Rheumatoid Arthritis Progression  CreakyJoints
Osteoarthritis - World Health Organization
Osteoarthritis  World Health Organization
Arthritis drug effective in treating sickest COVID-19 patients - Imperial College London
Arthritis drug effective in treating sickest COVID-19 patients  Imperial College London
Rheumatoid arthritis: features, causes and diagnosis - The Pharmaceutical Journal
Rheumatoid arthritis: features, causes and diagnosis  The Pharmaceutical Journal
Rheumatoid arthritis diagnosis and management: a clinical update - Nursing Times
Rheumatoid arthritis diagnosis and management: a clinical update  Nursing Times
Championing physio for inflammatory arthritis - Chartered Society of Physiotherapy
Championing physio for inflammatory arthritis  Chartered Society of Physiotherapy
Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis - nejm.org
Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis  nejm.org
Rheumatoid arthritis - The Lancet
Rheumatoid arthritis  The Lancet
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients - Nature.com
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients  Nature.com
11 Signs Your Rheumatoid Arthritis May Be Getting Worse, and You Should See a Doctor - CreakyJoints
11 Signs Your Rheumatoid Arthritis May Be Getting Worse, and You Should See a Doctor  CreakyJoints
Arthritis drugs may reduce mortality and time in ICU for sickest COVID patients - Imperial College London
Arthritis drugs may reduce mortality and time in ICU for sickest COVID patients  Imperial College London
Palliative care - World Health Organization
Palliative care  World Health Organization
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes - Nature.com
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes  Nature.com
Effect of tight control of inflammation in early psoriatic arthritis (TICOPA): a UK multicentre, open-label, randomised controlled trial - The Lancet
Effect of tight control of inflammation in early psoriatic arthritis (TICOPA): a UK multicentre, open-label, randomised controlled trial  The Lancet
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission - Nature.com
Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission  Nature.com
Signaling pathways in rheumatoid arthritis: implications for targeted therapy - Nature.com
Signaling pathways in rheumatoid arthritis: implications for targeted therapy  Nature.com
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment - Nature.com
Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment  Nature.com
Adalimumab is found to be a cost-effective treatment for early-stage Dupuytren's disease - Nuffield Department of Population Health
Adalimumab is found to be a cost-effective treatment for early-stage Dupuytren's disease  Nuffield Department of Population Health
Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY - The Lancet
Gout incidence and management during the COVID-19 pandemic in England, UK: a nationwide observational study using OpenSAFELY  The Lancet
What Are Common Symptoms of Autoimmune Disease? - Johns Hopkins Medicine
What Are Common Symptoms of Autoimmune Disease?  Johns Hopkins Medicine
Identification of SNPs associated with methotrexate treatment outcomes in patients with early rheumatoid arthritis - Frontiers
Identification of SNPs associated with methotrexate treatment outcomes in patients with early rheumatoid arthritis  Frontiers
Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol - Trials Journal
Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol  Trials Journal
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal - Health Central
Rheumatoid Arthritis & Jaw Pain: Here's How to Deal  Health Central
Rheumatoid Arthritis X-Ray: Diagnosis and Evaluation - Health Central
Rheumatoid Arthritis X-Ray: Diagnosis and Evaluation  Health Central
Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK - The BMJ
Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK  The BMJ
Arthritis symptoms, treatments and foods that can help - The Telegraph
Arthritis symptoms, treatments and foods that can help  The Telegraph
Blocking the immune system in rheumatoid arthritis - The Pharmaceutical Journal
Blocking the immune system in rheumatoid arthritis  The Pharmaceutical Journal
Treatment to target in rheumatoid arthritis - Nursing Times
Treatment to target in rheumatoid arthritis  Nursing Times
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis - Nature.com
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis  Nature.com
Identification of novel urinary biomarkers for assessing disease activity and prognosis of rheumatoid arthritis - Nature.com
Identification of novel urinary biomarkers for assessing disease activity and prognosis of rheumatoid arthritis  Nature.com
UK waiting times for RA and PsA patients: an interview with Dr Marwan Bukhari, Consultant Rheumatologist at the University Hospitals of Morecambe Bay NHS Foundation Trust - News-Medical.Net
UK waiting times for RA and PsA patients: an interview with Dr Marwan Bukhari, Consultant Rheumatologist at the University Hospitals of Morecambe Bay NHS Foundation Trust  News-Medical.Net
Early Menopause, Hormone Replacement Therapy May Raise Rheumatoid Arthritis Risk - Healthline
Early Menopause, Hormone Replacement Therapy May Raise Rheumatoid Arthritis Risk  Healthline
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics - Nature.com
Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics  Nature.com
Early treatment of rheumatoid arthritis could 'reverse' health risks - HeraldScotland
Early treatment of rheumatoid arthritis could 'reverse' health risks  HeraldScotland
Rheumatoid arthritis: management - The Pharmaceutical Journal
Rheumatoid arthritis: management  The Pharmaceutical Journal
Biological disease‐modifying drugs for rheumatoid arthritis - Chaplin - 2020 - Prescriber - Wiley Online Library
Biological disease‐modifying drugs for rheumatoid arthritis - Chaplin - 2020 - Prescriber  Wiley Online Library
Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein CTLA4Ig - nejm.org
Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein CTLA4Ig  nejm.org
Epidemiology and clinical characteristics of interstitial lung disease in patients with rheumatoid arthritis from the JointMan database - Nature.com
Epidemiology and clinical characteristics of interstitial lung disease in patients with rheumatoid arthritis from the JointMan database  Nature.com
IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function - Frontiers
IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function  Frontiers
6 Common Questions About Taking Prednisone for Rheumatoid Arthritis - CreakyJoints
6 Common Questions About Taking Prednisone for Rheumatoid Arthritis  CreakyJoints
Reactive Arthritis Following COVID-19 Infection: What to Know - Healthline
Reactive Arthritis Following COVID-19 Infection: What to Know  Healthline
Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health - Nature.com
Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health  Nature.com
Low-Dose Prednisone Inclusion in a Methotrexate-Based, Tight Control Strategy for Early Rheumatoid Arthritis: - Annals of Internal Medicine
Low-Dose Prednisone Inclusion in a Methotrexate-Based, Tight Control Strategy for Early Rheumatoid Arthritis:  Annals of Internal Medicine
10 Natural remedies for rheumatoid arthritis - Medical News Today
10 Natural remedies for rheumatoid arthritis  Medical News Today
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients - Nature.com
Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients  Nature.com
Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis - Nature.com
Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis  Nature.com
29 Tips from Podiatrists for Managing Arthritis Pain in Your Feet - CreakyJoints
29 Tips from Podiatrists for Managing Arthritis Pain in Your Feet  CreakyJoints
Laryngeal Manifestations of Rheumatoid Arthritis - Hamdan - 2013 - Autoimmune Diseases - Wiley Online Library
Laryngeal Manifestations of Rheumatoid Arthritis - Hamdan - 2013 - Autoimmune Diseases  Wiley Online Library
Vivian P. Bykerk, BSc, MD, FRCPC - hss.edu
Vivian P. Bykerk, BSc, MD, FRCPC  hss.edu
Characteristic-specific rates of rheumatoid arthritis and its management in Australian general practice - RACGP
Characteristic-specific rates of rheumatoid arthritis and its management in Australian general practice  RACGP
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis - nejm.org
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis  nejm.org
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis - nejm.org
The Effect of Glucocorticoids on Joint Destruction in Rheumatoid Arthritis  nejm.org

Articles/peer reviewed publications and
Lay Summaries

  • B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure.
    Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C; PEAC- R4RA investigators. 
    Arthritis Rheumatol. 2019 Nov 29.
    https://doi.org/10.1002/art.41184
    See Lay Summary




The R4-RA trial is funded by the MRC-NIHR Efficacy and
Mechanism Evaluation Programme